Ghum Hai Kisikey Pyaar Meiin

Sai Joshi is a young and outspoken girl, living with her father Inspector Kamal Joshi, in Gadchiroli. She aspires to become a doctor and dreams to study MBBS at the Nagpur Medical College. In Nagpur, Virat Chavan becomes an officer and is posted at Gadchiroli. The local politician's son and goon, Jagtap, falls into a one-sided love with Sai and harasses her. Jagtap tries to kill Kamal in order to marry Sai. On topping 12th exam in Maharashtra state, Sai requests her father to take retirement and move to Nagpur. Virat joins his posting in Gadchiroli. Virat's car splashes mud on Sai which makes Sai dislike him. Further, Virat asks Kamal to postpone his VRS on stage. Kamal accepts his senior officer Virat's order which makes Sai angry. Virat and Pakhi become infatuated with each other but the Chavan family selects Pakhi as Samrat's bride. Pakhi in order to stay with Virat marries Samrat and Virat promises Pakhi to not give her place to any girl. Pakhi confesses her love to Virat which Samrat overhears and leaves for duty, heartbroken.

Kamal Joshi takes the bullet to save Virat from Jagtap's shot which Sai witnesses. On his deathbed, Kamal asks Virat to take care of Sai. Sai then attempts suicide. After Kamal's funeral, villagers pressurise Virat to marry orphaned Sai. Sai requests Virat to decline the marriage proposal and reminds him about Pakhi. Virat proposes a compromise marriage and unwillingly, Sai agrees to it. During the marriage, Virat reminds Sai to not expect any husbandly love and support from him as he already made a promise to Pakhi. Sai also makes it clear that she will leave their marriage once she completes her MBBS. Pakhi is upset by Virat and Sai's marriage but Virat assures her by disclosing the marriage's details. The Chavan family refuses to accept Virat and Sai's marriage as Sai is not from an upper class, Shahānnau Kule Maratha, like Pakhi. The Chavan family humiliates Sai by name-calling, defaming Kamal's death and his upbringing.

Pakhi and the Chavan family humiliate Sai and ask Sai to apologize to Pakhi. Sai has an emotional breakdown due to constant bullying and harassment and agrees with their claim of calling herself incompetent and unfit to be in the Chavan family. Ninad's childhood dream is realised when Sai surprises him with a Harmonium, which Sai bought with her scholarship money. Ninad is speechless and gives his blessing to Sai. Pakhi traps Ajinkya to meet an unwell Sai in the bedroom and the Chavan family sees Pakhi's action but remains mute. Virat gets angry and harms Ajinkya physically and questions Sai's character. Sai feels hurt and leaves the house but is hit a by car. Virat apologizes to Sai by crying in front of Kamal's photo and she forgives him.

Virat plans a trip to Mahabaleshwar to celebrate their marriage anniversary. But he lies to Sai and the Chavan family that this trip is an official one. The Chavan family sympathizes with Pakhi. Virat narrates a fake love story to Sai but the Yoga instructor interrupts them and speaks about Virat-Pakhi's love story. Sai becomes agitated as she thinks Virat was telling Pakhi and his love story which could not be completed due to her. They have an argument over their anniversary celebration and Sai leaves. Virat is hurt by Sai's behavior and seeks vengeance.

Pakhi host Pooja and invite Whole family but Sai refused to attend as she knows Pakhi is just pretending to be with Samrat. Virat instruct Sai to attend Pooja instead of going college Sai became adamant. Virat locks Sai in the room to prevent her from attending college. Sai leaves the house, then has an accident and is hospitalized. She later returns home. Sai and Virat restart their relationship as friends, but Pakhi loves him too.

The Police department suspends Virat for bigamy. To save Virat's job and reputation, Sai asks for a divorce and submits backdated divorce papers to the Police department. So they ask him to rejoin duty. Sada is still alive and learns of Shruti's affair with Virat, so he kidnaps Sai and asks Shruti to return. Virat is injured in a landmine blast while rescuing Sai and the Police arrest Shruti and Sada for their crimes. Sai arranges a life-saving injection for Virat and he regains consciousness. But he blames Sai for his condition and requests that the police release Shruti from all charges.

Sai returns to Chavan Niwas during Holi. The Chavan family supports Pakhi when she suggests throwing Sai into the Holi fire to be rid of her. On Holi, Sai brings Virat to the Holi function. The next day, Sai reads a letter from Shivani's ex-fiancé Rajeev. He tells Sai about feeling guilty after leaving Shivani and tells her that he only loved Shivani. Virat sees him and imprisons him. Sai informs Shivani that Rajeev felt guilty after leaving her and wants to patch up. The two women visit Rajeev in jail and Shivani forgives Rajeev.

Later he informs Sai that he lied to Bhavani about their future and encourages Sai to continue her internship, hiding from the family. The family realizes Virat's lie and the family's males support Sai. Soon Sai is revealed to be pregnant while Pakhi falls for Samrat. However, Jagtap kidnaps Sai and in his attempt to save her, Samrat is run over by Jagtap leading to his death. Pakhi blames Sai for the same and curses her due to which she suffers a miscarriage and becomes incapable to conceive. Sai and Virat hire a woman named Geeta to carry their child by becoming his surrogate mother but Pakhi manipulates the woman and becomes the surrogate mother of the baby with the intention to get close with Virat. She blackmailed Sai by traveling to Mahabaleshwar during her pregnancy time without informing anyone and standing on the peak of the mountain and start blackmailing by putting conditions in front of Virat and Sai that if Sai promise to Pakhi that she will not come close to her and only Virat will take care of her during the whole pregnancy. On the baby shower day Pakhi challenges Sai that she will not hand over the baby after born, and with the help of the baby she will enter Virat's life, She also threatens Sai that if she informed the same to others she will refuse to accept. Sai decide to keep quiet until delivery as she doesn't want chaos in the family and she is more concerned about her unborn baby's health. Soon Pakhi feels labor pain at that movement no one is home, and Nagpur having disastrous rain, somehow Virat reaches home and do delivery on the instructions of Sai. The moment when Sai holds her child she decides to forgive Pakhi and asks her to same and wants a fresh relationship. But Pakhi does a drama of suicide and Unwillingly, the family members take away Vinayak from Sai and give him to Pakhi. Now Sai is on a mission to find the truth and within 15 days she found all evidence that proves that Pakhi manipulated Geeta, and sent goons to attack Sai so she can't reach Geeta.

Sai has Pakhi arrested in a case of illegal surrogacy and manipulating Geeta. The family members ask Sai to let them bail out Pakhi but she refuses and threatens to leave the house along with Vinayak if they return Pakhi. Virat bails Pakhi out and brings her to Chavan Nivas. Sai leaves the house along with Vinayak. As she travels to Gadhchiroli on a bus, there is an accident. Virat reaches the accident spot and looks for Sai and Vinayak. Virat and the family members consider Sai dead and do her final rites. Sai survives and searches for Vinayak in vain. She thinks that Vinayak is dead and falls unconscious. She regains consciousness in the hospital and discovers that she is pregnant.

7 years later

Later, Virat and Vinayak return to Nagpur and are welcomed by Bhavani, who has become an MLA and Pakhi, who now owns the family business and became Virat's second wife on the Chavan's insistence and came to a compromise with Virat that they will be husband and wife just for their namesake. Virat still remembers Sai and considers himself responsible for letting her go. Ashwini hates Sai for leaving Virat and tells him to forget her. Later, Bhavani and Ashwini plan a holiday for Pakhi and Virat but they refuse to do so. Later, Virat and Vinayak go to Kankavli to meet Sai and Savi for Vinayak's treatment. Virat is shocked to see Sai alive and is angry with her and asks her about Savi. Later, Gulabrao insults Sai and questions her character and Virat beats him up. Later, Gulabrao's men kidnap Savi and attempt to kill her but Virat saves her and ends up getting hurt. Pakhi urgently goes to Kankavli to meet Virat along with Mohit and is shocked to see Sai alive. Later, Virat and Pakhi return to Nagpur along with Vinayak and the family members get to know about Sai and Savi and break ties with Sai. Later, Vinayak's health deteriorates and Pakhi requests Sai to come to Nagpur for Vinayak's treatment. She agrees and comes to Nagpur and stays in a rented house along with Savi and Usha. Sai treats Vinayak and he is able to walk freely. Jagtap tells Virat about Savi being his daughter and Virat stops Sai and takes Savi from her and gets her arrested.

The bus falls down and Pakhi gets severely injured. The doctors declare Pakhi dead but Sai revives her and operates her successfully. Pakhi is irked from Virat. Virat later accepts Pakhi as his wife and starts afresh. Later, Bhavani sends Virat and Pakhi on a honeymoon trip. Over there, Virat meets a couple and they reveal that a few years ago when they were going to Gadhchiroli from Nagpur by bus and their bus meets an accident. Virat decided to find his lost son.

Sai takes Savi and Vinayak to Lonavla for an outing and meets Sahiba Monga, an artist during a social gathering and tells her story to her. Sai gets a job in a hospital in Nagpur and meets Sahiba again and work together. Later, a patient kidnaps Savi and Vinayak and keeps them in his custody. On hearing this, Pakhi falls unconscious and her health deteriorates. Sahiba, Sai, and Virat rescue them and Saheba goes back to Ludhiana. Virat discovers that Vinayak is his long-lost son which he adopted a long time ago. Pulkit tells the family that Pakhi's uterus has to be removed else she will die. Virat agrees to it and Pulkit and Sai save her life. Pakhi is devastated on hearing that her uterus was removed and she can never conceive. Later, Shivani reveals to the family that she is pregnant for 3 months. Bhavani hurls a taunt at her and goes away.

Pakhi files a case against Pulkit and Sai for removing her uterus but Pakhi loses the case. Later, Vinayak reunites with Sai and Sai plans to leave the house. Later, Virat goes on a mission but gets shot. Sai arrives there and Virat confesses his love for her. Sai fears that she will be the reason for breaking Pakhi's married life and decides to leave Virat forever. Virat locks her up in the house but Sai escapes. Virat goes behind her and finally meets Sai in a public gathering in which Bhavani was the chief guest. Virat confesses his love in public and as the public forces her, Sai agrees to marry him. Ashwini tells Sai to marry Satya. Sai tells Satya to marry her and both marry and Virat is left heartbroken. Pakhi realizes that Virat had never loved her and leaves him for good. It is revealed that Amba was Bhavani's sister who ran away with a person in the past and later that person left her while she was pregnant. Sai and Virat get closer and Satya gets irked because of their closeness. Later, It was revealed that Satya's father is Vijendra Ghatge who was Sai's father's colleague who had Last Stage Brain Tumour. Vijendra and Amba reunite and get married. Vijendra had undergone surgery and the surgery was successful. Satya gets injured and his legs get paralyzed. Sai consults the doctors and they advise her to take Satya to Germany. Later, Sai visits Chavan's house for the last time and leave for the airport. Later, Ashwini and Bhavani decide to go to Mumbai with the entire family to go to Siddhivinayak Temple. Virat arrests a criminal Ramakant Pujari due to which his aides led by Bheema Pujari decide to teach the Police a lesson by hijacking a flight to Mumbai. Savi overhears their conversation and tells it to Virat and Sai.

20 years later