Alpha-glucan, water dikinase
In enzymology, an alpha-glucan, water dikinase (EC 2.7.9.4) is an enzyme that catalyzes the chemical reaction
- ATP + alpha-glucan + H2O AMP + phospho-alpha-glucan + phosphate
| alpha-glucan, water dikinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.9.4 | ||||||||
| CAS no. | 664327-94-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are ATP, alpha-glucan, and H2O, whereas its 3 products are AMP, phospho-alpha-glucan, and phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with paired acceptors (dikinases). The systematic name of this enzyme class is ATP:alpha-glucan, water phosphotransferase. This enzyme is also called starch-related R1 protein, GWD.
References
- Ritte G, Lloyd JR, Eckermann N, Rottmann A, Kossmann J, Steup M (2002). "The starch-related R1 protein is an alpha -glucan, water dikinase". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7166–71. Bibcode:2002PNAS...99.7166R. doi:10.1073/pnas.062053099. PMC 124546. PMID 12011472.
- Ritte G, Heydenreich M, Mahlow S, Haebel S, Kotting O, Steup M (2006). "Phosphorylation of C6- and C3-positions of glucosyl residues in starch is catalysed by distinct dikinases". FEBS Lett. 580 (20): 4872–6. doi:10.1016/j.febslet.2006.07.085. PMID 16914145.
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