Glycerol-3-phosphate oxidase

In enzymology, a glycerol-3-phosphate oxidase (EC 1.1.3.21) is an enzyme that catalyzes the chemical reaction

sn-glycerol 3-phosphate + O2 glycerone phosphate + H2O2
glycerol-3-phosphate oxidase
Identifiers
EC no.1.1.3.21
CAS no.9046-28-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are sn-glycerol 3-phosphate and O2, whereas its two products are dihydroxyacetone phosphate (DHAP) and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:oxygen 2-oxidoreductase. Other names in common use include glycerol phosphate oxidase, glycerol-1-phosphate oxidase, glycerol phosphate oxidase, L-alpha-glycerophosphate oxidase, alpha-glycerophosphate oxidase, and L-alpha-glycerol-3-phosphate oxidase. This enzyme participates in glycerophospholipid metabolism. It employs one cofactor, FAD.

References

    • Gancedo C, Gancedo JM, Sols A (1968). "Glycerol metabolism in yeasts. Pathways of utilization and production". Eur. J. Biochem. 5 (2): 165–72. doi:10.1111/j.1432-1033.1968.tb00353.x. PMID 5667352.
    • Koditschek LK, Umbreit WW (1969). "Alpha-glycerophosphate oxidase in Streptococcus faecium F 24". J. Bacteriol. 98 (3): 1063–8. PMC 315296. PMID 5788698.


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