Gougerotin

Gougerotin
Identifiers
CAS Number	2096-42-6 ;
PubChem CID	11226719;
ChemSpider	9401772 ;
UNII	ALH0452B20;
ChEBI	CHEBI:156351;
Chemical and physical data
Formula	C16H25N7O8
Molar mass	443.417 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNCC(=O)NC(CO)C(=O)NC1C(C(C(OC1C(=O)N)N2C=CC(=NC2=O)N)O)O;
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Gougerotin is a water-soluble pyrimidine-based antibiotic which is produced by the bacteria Streptomyces graminearus and Streptomyces gougerotii.[1][2][3][4] Gougerotin is named after the dermatologist Henri-Eugène Gougerot.[2] Gougerotin has activity against Gram-positive and Gram-negative bacteria as well as against viruses.[2]

References

Yukioka M (1975). "Gougerotin". Mechanism of Action of Antimicrobial and Antitumor Agents: 448–458. doi:10.1007/978-3-642-46304-4_29. ISBN 978-3-642-46306-8.
"Gougerotin". www.spektrum.de (in German).
Comprehensive Natural Products III. Elsevier. p. 528. ISBN 978-0-08-102691-5.
"Gougerotin". www.spektrum.de (in German).

Clark JM, Gunther JK (December 1963). "Gougerotin, a specific inhibitor of protein synthesis". Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects. 76: 636–8. doi:10.1016/0926-6550(63)90092-6. PMID 14099625.
Burkett AR, Schlender KK, Sell HM (March 1970). "Gougerotin—an inhibitor of protein synthesis and auxin-induced elongation in plants". Phytochemistry. 9 (3): 545–547. doi:10.1016/S0031-9422(00)85687-3.
Gottlieb D, Shaw PD. Mechanism of Action. Springer Science & Business Media. p. 281. ISBN 978-3-642-46051-7.
Barbacid M, Vazquez D (May 1974). "(G-3H)gougerotin binding to ribosomes. Heterogeneity of eukaryotic ribosomes". European Journal of Biochemistry. 44 (2): 445–53. doi:10.1111/j.1432-1033.1974.tb03502.x. PMID 4600364.

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