HIST2H3A

Histone cluster 2 H3 family member a is a protein that in humans is encoded by the HIST2H3A gene. [5]

H3C15
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH3C15, H3/n, H3/o, histone cluster 2, H3a, histone cluster 2 H3 family member a, HIST2H3A, H3 clustered histone 15, H3C14, H3C13
External IDsMGI: 2448329 HomoloGene: 133885 GeneCards: H3C15
Orthologs
SpeciesHumanMouse
Entrez

333932

260423

Ensembl

ENSG00000203852

ENSMUSG00000100210

UniProt

Q71DI3

P84228

RefSeq (mRNA)

NM_001005464

NM_013548

RefSeq (protein)

NP_066403
NP_001116847

Location (UCSC)Chr 1: 149.85 – 149.85 MbChr 13: 23.73 – 23.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on human chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015].

References

  1. GRCh38: Ensembl release 89: ENSG00000203852 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000100210 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Histone cluster 2 H3 family member a". Retrieved 2018-08-05.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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