HIST3H2A

Histone H2A type 3 is a protein that in humans is encoded by the HIST3H2A gene.[5][6]

H2AW
Identifiers
AliasesH2AW, histone cluster 3 H2A, HIST3H2A, H2A.W histone
External IDsOMIM: 615015 MGI: 2448458 HomoloGene: 137357 GeneCards: H2AW
Orthologs
SpeciesHumanMouse
Entrez

92815

319162

Ensembl

ENSG00000181218
ENSG00000284841

ENSMUSG00000078851

UniProt

Q7L7L0

Q8BFU2

RefSeq (mRNA)

NM_033445

NM_178218

RefSeq (protein)

NP_254280

NP_835736

Location (UCSC)Chr 1: 228.43 – 228.46 MbChr 11: 58.85 – 58.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.[6]

References

  1. ENSG00000284841 GRCh38: Ensembl release 89: ENSG00000181218, ENSG00000284841 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000078851 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. "Entrez Gene: HIST3H2A histone cluster 3, H2a".

Further reading


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