HLA-Cw7

HLA-Cw7 (Cw7) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw7 is determined by the antibody recognition of α7 subset of HLA-Cw α-chains. For the serotype Cw7, the alpha chain are encoded by the HLA-Cw*07 allele group and the β-chain are encoded by B2M locus.[1] Cw7 and Cw*07 are almost synonymous in meaning. Cw7 is more common in West Africa to Ireland. Cw7 in Europe is part of the AH8.1 and HLA B7-DR15-DQ6 haplotypes. The class I region of these supertype is HLA A1-B8 haplotype, HLA A3-B7, HLA-A2-B7 and HLA A24-B7.

HLA-Cw7
(MHC Class I, C cell surface antigen)
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-Cw*07--, β2-microglobulin
Older names-
Subtypes
Subtype
allele
Available structures
Cw7 *0701
- *0702
{{{cNick3}}} *07{{{cAllele3}}}
{{{cNick4}}} *07{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

Serotype
Cw7 recognition of some HLA Cw*07 gene products[2]
Cw*07 Cw7 Sample
allele % size (N)
*070174304
*070268976


Distribution
HLA Cw*0701 frequencies
Study populationFreq.
 (in %)[3]
Cameroon Pygmy Baka25.0
Ireland South21.2
German Essen20.9
Cameroon Sawa19.2
Ireland Northern18.7
France West18.1
Kenya17.8
Burkina Faso Fulani17.4
Australia New South Wales17.3
France South East17.3
Morocco 'Berber' Nador Me…16.7
Sudanese16.5
United Kingdom Caucasians16.1
Uganda Kampala16.0
Brazil15.6
USA Caucasian (2)15.5
Kenya Nandi15.2
Pakistan Baloch15.2
Burkina Faso Rimaibe14.9
Finland14.4
Czech Republic14.2
Swiss Geneva13.6
South Africa Natal Tamil13.5
Cameroon Bamileke13.0
India Khandesh Pawra13.0
Cameroon Beti12.9
Tunisia12.6
India New Delhi12.5
Saudi Arabia Guraiat and …12.3
Turkey12.3
Zambia Lusaka12.2
Kenya Luo11.7
Burkina Faso Mossi11.3
South Korea (1)11.1
Spain Eastern Andalusia11.0
USA Hispanic10.9
Lebanon10.8
India Tamil Nadu Nadar10.7
Zimbabwe Harare Shona10.6
Russia Arkhangelsk Pomors10.0
Georgia Tbilisi Georgian…9.8
Mexico Zaptotec Oaxaca9.7
Israel Arab Druse9.0
Senegal Niokholo Mandenka8.7
USA North American Native…8.6
Pakistan Sindhi8.3
India North Delhi8.0
Iran Baloch7.8
Thailand7.7
Singapore Riau Malay7.5
India West Coast Parsis7.0
Georgia Tbilisi Kurds6.9
Pakistan Kalash6.5
Mali Bandiagara6.2
Pakistan Burusho5.6
Pakistan Karachi Parsi5.5
Pakistan Pathan5.5
Russia Murmansk Saomi4.0
Singapore Javanese Indone…4.0
India Mumbai Marathas3.7
Australia Indig. Cape Yor…3.4
Pakistan Brahui3.4
India West Bhils3.0
China North Han2.9
Jordan Amman2.8
China Inner Mongolia2.5
Italy North Pavia2.5
Russia Nenets2.4
China Qinghai Hui2.3
Australia Indig. Groote E…2.1
Russia Tuva (2)2.0
USA Hawaii Okinawa1.9
USA Asian1.8
China South Han1.6
China Beijing1.5
Papua New Guinea Wanigela1.4
Allele frequencies presented, only
HLA Cw*0702 frequencies
Study populationFreq.
 (in %)[3]
Venezuela Sierra de Perij…71.4
PNG New Britain Rabaul57.1
Mexico Mixtec Oaxaca33.3
China Yunnan Lisu32.9
Taiwan Taroko31.8
China Yunnan Nu30.7
Venezuela Perja Mountain …30.3
PNG Madang30.2
Mexico Zaptotec Oaxaca28.4
Taiwan Tsou27.5
Mexico Mixe Oaxaca26.4
Russia Arkhangelsk Pomors26.0
Ch. Guangdong Meizhou H…25.8
Pakistan Burusho25.5
USA South Dakota Lakota S…24.4
Russia Nenets23.8
USA New Mexico Canoncito …23.2
China South Han20.8
Brazil Terena20.2
China Guangzhou19.9
USA Asian19.5
Ireland Northern18.6
Swiss Geneva18.2
Taiwan Bunun17.8
Ireland South17.4
Singapore Javanese Indone…17.0
Philippines Ivatan16.0
Taiwan Rukai16.0
Australia New South Wales15.8
Finland15.6
USA South Texas Hispanics15.6
Pakistan Sindhi15.5
United Kingdom Caucasians15.5
Saudi Arabia Guraiat and …15.2
Cameroon Pygmy Baka15.0
India Tamil Nadu Nadar14.8
Japan Central14.6
Russia Murmansk Saomi14.0
USA Hawaii Okinawa13.8
China Beijing13.6
China Tibetan13.3
China Qinghai Hui13.2
Thailand13.0
USA North American Native…12.8
China Inner Mongolia12.7
Japan (3)12.7
Pakistan Brahui12.5
PNG Wanigela12.5
USA Caucasian pop212.5
USA Hispanic12.4
Czech Republic12.3
China North Han11.9
Taiwan Paiwan11.8
China Wuhan11.6
Cameroon Sawa11.5
Taiwan Siraya10.8
Taiwan Ami10.7
New Caledonia10.0
India North Delhi9.9
Australia Indig. Cape Yor…9.6
Pakistan Pathan9.5
France West9.4
Iran Baloch9.4
South Africa Natal Tamil9.4
German Essen9.1
Taiwan Puyuma9.0
India New Delhi8.9
Pakistan Kalash8.7
India Mumbai Marathas8.6
Russia Tuva pop 28.6
South Korea (3)8.3
American Samoa8.0
Brazil8.0
USA African American8.0
France South East7.2
Cameroon Bamileke7.1
India West Bhils7.0
Australia Indig. Yuendumu6.8
Cameroon Beti6.6
Georgia Tbilisi Georgian…6.5
Uganda Kampala6.1
Turkey6.0
Spain Eastern Andalusia5.5
PNG Wosera5.4
Mali Bandiagara4.7
Zimbabwe Harare Shona4.6
Mexico Chihuahua State Ta…4.5
Pakistan Baloch4.5
Kenya4.4
Zambia Lusaka4.4
Lebanon4.1
Israel Arab Druse4.0
Kenya Luo3.8
Tunisia3.6
PNG Eastern Highlands Gor…3.5
Sudanese3.5
Georgia Tbilisi Kurds3.4
Morocco 'Berber' Nador Me…3.2
England London Ashkenazi …2.9
Allele frequencies presented, only

References
  1. Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. Allele Query Form IMGT/HLA - European Bioinformatics Institute
  3. Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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