Hydroxynitrilase

In enzymology, a hydroxynitrilase (EC 4.1.2.37) is an enzyme that catalyzes the chemical reaction

acetone cyanohydrin cyanide + acetone
acetone-cyanhydrin lyase
Identifiers
EC no.4.1.2.37
CAS no.112567-89-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Hence, this enzyme has one substrate, acetone cyanohydrin, and two products, cyanide and acetone.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is acetone-cyanohydrin acetone-lyase (cyanide-forming). Other names in common use include alpha-hydroxynitrile lyase, hydroxynitrile lyase, acetone-cyanhydrin lyase [mis-spelt], acetone-cyanohydrin acetone-lyase, oxynitrilase, 2-hydroxyisobutyronitrile acetone-lyase, 2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming), and acetone-cyanohydrin lyase.

References

    • Xu LL, Singh BK, Conn EE (1988). "Purification and characterization of acetone cyanohydrin lyase from Linum usitatissimum". Arch. Biochem. Biophys. 263 (2): 256–63. doi:10.1016/0003-9861(88)90634-0. PMID 3377504.
    • Selmar D, Lieberei R, Biehl B, Conn EE (1989). "alpha-Hydroxynitrile lyase in Hevea brasiliensis and its significance for rapid cyanogenesis". Physiol. Plant. 75: 97–101. doi:10.1111/j.1399-3054.1989.tb02069.x.


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