Hygromycin-B kinase

In enzymology, a hygromycin-B kinase (EC 2.7.1.119) is an enzyme that catalyzes the chemical reaction

ATP + hygromycin B ADP + 7"-O-phosphohygromycin
hygromycin B kinase
Identifiers
EC no.2.7.1.119
CAS no.88361-67-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

Thus, the two substrates of this enzyme are ATP and hygromycin B, whereas its two products are ADP and 7''-O-phosphohygromycin.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:hygromycin-B 7"-O-phosphotransferase. This enzyme is also called hygromycin B phosphotransferase.

References

    • Zalacain M, Pardo JM, Jimenez A (1987). "Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus". Eur. J. Biochem. 162 (2): 419–22. doi:10.1111/j.1432-1033.1987.tb10618.x. hdl:10261/57133. PMID 3026811.
    • Pardo JM, Malpartida F, Rico M, Jimenez A (1985). "Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus - the producing organism". J. Gen. Microbiol. 131 (6): 1289–1298. doi:10.1099/00221287-131-6-1289. PMID 2995542.


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