IGF2BP2

Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene.[5][6][7]

IGF2BP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIGF2BP2, IMP-2, IMP2, VICKZ2, insulin like growth factor 2 mRNA binding protein 2
External IDsOMIM: 608289 MGI: 1890358 HomoloGene: 4774 GeneCards: IGF2BP2
Orthologs
SpeciesHumanMouse
Entrez

10644

319765

Ensembl

ENSG00000073792

ENSMUSG00000033581

UniProt

Q9Y6M1

Q5SF07

RefSeq (mRNA)

NM_183029

RefSeq (protein)

NP_898850

Location (UCSC)Chr 3: 185.64 – 185.83 MbChr 16: 21.88 – 21.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000073792 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033581 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhang JY, Chan EK, Peng XX, Tan EM (May 1999). "A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma". J Exp Med. 189 (7): 1101–10. doi:10.1084/jem.189.7.1101. PMC 2193003. PMID 10190901.
  6. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC 116055. PMID 9891060.
  7. "Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2".

Further reading


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