IGF2BP3

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene.[5][6][7]

IGF2BP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIGF2BP3, CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3, insulin like growth factor 2 mRNA binding protein 3
External IDsOMIM: 608259 MGI: 1890359 HomoloGene: 4773 GeneCards: IGF2BP3
Orthologs
SpeciesHumanMouse
Entrez

10643

140488

Ensembl

ENSG00000136231

ENSMUSG00000029814

UniProt

O00425

Q9CPN8

RefSeq (mRNA)

NM_006547

NM_023670

RefSeq (protein)

NP_006538

NP_076159

Location (UCSC)Chr 7: 23.31 – 23.47 MbChr 6: 49.06 – 49.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development.

The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000136231 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029814 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC 116055. PMID 9891060.
  6. Mueller-Pillasch F, Lacher U, Wallrapp C, Micha A, Zimmerhackl F, Hameister H, Varga G, Friess H, Buchler M, Beger HG, Vila MR, Adler G, Gress TM (Jul 1997). "Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein". Oncogene. 14 (22): 2729–33. doi:10.1038/sj.onc.1201110. PMID 9178771.
  7. "Entrez Gene: IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3".

Further reading


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