Interleukin 12 receptor, beta 2 subunit

Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene.[5] IL12RB2 orthologs[6] have been identified in all mammals for which complete genome data are available.

IL12RB2
Identifiers
AliasesIL12RB2, Interleukin 12 receptor, beta 2 subunit, interleukin 12 receptor subunit beta 2
External IDsOMIM: 601642 MGI: 1270861 HomoloGene: 1197 GeneCards: IL12RB2
Orthologs
SpeciesHumanMouse
Entrez

3595

16162

Ensembl

ENSG00000081985

ENSMUSG00000018341

UniProt

Q99665

P97378

RefSeq (mRNA)

NM_008354
NM_001311141

RefSeq (protein)

NP_001298070
NP_032380

Location (UCSC)Chr 1: 67.31 – 67.4 MbChr 6: 67.27 – 67.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The co-expression of this and IL12Rβ1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. While the IL12Rβ1 subunit is constitutively expressed, the expression of the IL12RB2 gene is up-regulated by interferon gamma. In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL12Rβ2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules.[7] The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.[5]

Interactions

Interleukin 12 receptor, beta 2 subunit has been shown to interact with Janus kinase 2.[8]

RNA editing

The mRNA of this protein is subject to RNA editing.

References

  1. GRCh38: Ensembl release 89: ENSG00000081985 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018341 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: IL12RB2 interleukin 12 receptor, beta 2".
  6. "OrthoMaM phylogenetic marker: IL12RB2 coding sequence".
  7. Koch MA, Thomas KR, Perdue NR, Smigiel KS, Srivastava S, Campbell DJ (September 2012). "T-bet(+) Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2". Immunity. 37 (3): 501–10. doi:10.1016/j.immuni.2012.05.031. PMC 3501343. PMID 22960221.
  8. Yamamoto, K; Shibata F; Miura O; Kamiyama R; Hirosawa S; Miyasaka N (April 1999). "Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus". Biochem. Biophys. Res. Commun. UNITED STATES. 257 (2): 400–4. doi:10.1006/bbrc.1999.0479. ISSN 0006-291X. PMID 10198225.

Further reading


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