IL1RAP

Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.[5][6][7]

IL1RAP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL1RAP, C3orf13, IL-1RAcP, IL1R3, interleukin 1 receptor accessory protein
External IDsOMIM: 602626 MGI: 104975 HomoloGene: 1643 GeneCards: IL1RAP
Orthologs
SpeciesHumanMouse
Entrez

3556

16180

Ensembl

ENSG00000196083

ENSMUSG00000022514

UniProt

Q9NPH3

Q61730

RefSeq (mRNA)

NM_001159317
NM_001159318
NM_008364
NM_134103

RefSeq (protein)

NP_001152789
NP_001152790
NP_032390
NP_598864

Location (UCSC)Chr 3: 190.51 – 190.66 MbChr 16: 26.4 – 26.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.[7]

Interactions

IL1RAP has been shown to interact with TOLLIP[8] and Interleukin 1 receptor, type I.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000196083 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022514 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dale M, Hammond DW, Cox A, Nicklin MJ (April 1998). "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 47 (2): 325–6. doi:10.1006/geno.1997.5113. PMID 9479509.
  6. Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J Biol Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
  7. "Entrez Gene: IL1RAP interleukin 1 receptor accessory protein".
  8. Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. ENGLAND. 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325. S2CID 32036101.
  9. Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 94 (24): 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9NPH3 (Human Interleukin-1 receptor accessory protein) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: Q61730 (Mouse Interleukin-1 receptor accessory protein) at the PDBe-KB.
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