IL1RAP
Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.[5][6][7]
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.[7]
Interactions
IL1RAP has been shown to interact with TOLLIP[8] and Interleukin 1 receptor, type I.[9]
References
- GRCh38: Ensembl release 89: ENSG00000196083 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000022514 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Dale M, Hammond DW, Cox A, Nicklin MJ (April 1998). "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 47 (2): 325–6. doi:10.1006/geno.1997.5113. PMID 9479509.
- Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J Biol Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
- "Entrez Gene: IL1RAP interleukin 1 receptor accessory protein".
- Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. ENGLAND. 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325. S2CID 32036101.
- Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 94 (24): 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.
Further reading
- Greenfeder SA, Nunes P, Kwee L, et al. (1995). "Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex". J. Biol. Chem. 270 (23): 13757–65. doi:10.1074/jbc.270.23.13757. PMID 7775431.
- Parnet P, Garka KE, Bonnert TP, et al. (1996). "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP". J. Biol. Chem. 271 (8): 3967–70. doi:10.1074/jbc.271.8.3967. PMID 8626725.
- Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. PMC 24223. PMID 9371760.
- Cullinan EB, Kwee L, Nunes P, et al. (1998). "IL-1 receptor accessory protein is an essential component of the IL-1 receptor". J. Immunol. 161 (10): 5614–20. doi:10.4049/jimmunol.161.10.5614. PMID 9820540. S2CID 22101221.
- Lang D, Knop J, Wesche H, et al. (1999). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness". J. Immunol. 161 (12): 6871–7. doi:10.4049/jimmunol.161.12.6871. PMID 9862719. S2CID 8940186.
- Morton NM, de Groot RP, Cawthorne MA, Emilsson V (1999). "Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells". FEBS Lett. 442 (1): 57–60. doi:10.1016/S0014-5793(98)01623-8. PMID 9923604. S2CID 81592992.
- Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit". Mol. Cell. Biol. 19 (7): 4798–805. doi:10.1128/mcb.19.7.4798. PMC 84278. PMID 10373529.
- Jensen LE, Muzio M, Mantovani A, Whitehead AS (2000). "IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein". J. Immunol. 164 (10): 5277–86. doi:10.4049/jimmunol.164.10.5277. PMID 10799889.
- Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325. S2CID 32036101.
- Bigonnesse F, Marois M, Maheux R, Akoum A (2001). "Interleukin-1 receptor accessory protein is constitutively expressed in human endometrium throughout the menstrual cycle". Mol. Hum. Reprod. 7 (4): 333–9. doi:10.1093/molehr/7.4.333. PMID 11279295.
- Jefferies C, Bowie A, Brady G, et al. (2001). "Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1" (PDF). Mol. Cell. Biol. 21 (14): 4544–52. doi:10.1128/MCB.21.14.4544-4552.2001. PMC 87113. PMID 11416133.
- Radons J, Gabler S, Wesche H, et al. (2002). "Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling". J. Biol. Chem. 277 (19): 16456–63. doi:10.1074/jbc.M201000200. PMID 11880380.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ruhul Amin AR, Machida K, Oshima K, et al. (2003). "A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling". Oncogene. 21 (57): 8871–8. doi:10.1038/sj.onc.1206018. PMID 12483539.
- Smith DE; Hanna R; Della Friend; et al. (2003). "The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action". Immunity. 18 (1): 87–96. doi:10.1016/S1074-7613(02)00514-9. PMID 12530978.
- Boch JA, Yoshida Y, Koyama Y, et al. (2003). "Characterization of a cascade of protein interactions initiated at the IL-1 receptor". Biochem. Biophys. Res. Commun. 303 (2): 525–31. doi:10.1016/S0006-291X(03)00385-1. PMID 12659850.
- Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
- Jensen LE, Whitehead AS (2004). "Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis". Cell. Signal. 15 (8): 793–802. doi:10.1016/S0898-6568(03)00039-1. PMID 12781872.
External links
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