Interleukin 20 receptor, beta subunit

Interleukin 20 receptor, beta subunit (IL20R2 or IL20RB) is a subunit of the interleukin-20 receptor and interleukin-22 receptor. It is believed to be involved in both pro-inflammatory and anti-inflammatory responses.[5][6]

IL20RB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL20RB, DIRS1, FNDC6, IL-20R2, Interleukin 20 receptor, beta subunit, interleukin 20 receptor subunit beta
External IDsOMIM: 605621 MGI: 2143266 HomoloGene: 86034 GeneCards: IL20RB
Orthologs
SpeciesHumanMouse
Entrez

53833

213208

Ensembl

ENSG00000174564

ENSMUSG00000044244

UniProt

Q6UXL0

E9Q9A6

RefSeq (mRNA)

NM_144717

NM_001033543
NM_001037246

RefSeq (protein)

NP_653318

NP_001028715

Location (UCSC)Chr 3: 136.95 – 137.01 MbChr 9: 100.34 – 100.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RB is also found in some immune cells.[7] The subunit has been linked with multiple diseases, including gastrointestinal diseases and glaucoma.

Structure and function

IL20RB is a β-chain with a short intracellular domain. IL20RB, along with the IL-20 receptor, alpha subunit, form the heterodimeric type I interleukin-20 receptor, which binds the cytokines IL-20 and IL-24. IL20RB also associates with IL-22 receptor, to form the heterodimeric type II interleukin-20 receptor, which also binds IL-20 and IL-24.[6]

Signaling

After a cytokine binds both the IL20RB and the alpha subunit of the IL20 receptor, a signal is sent through the JAK-STAT signaling pathway. This signaling pathway leads STAT to act as a transcription factor, which can gene expression.[6]

IL20RB mRNA is present in some immune cells, including monocytes, natural killer cells, B-cells, T-cells, and some hematopoietic stem cells. It is known what role IL20RB plays in these cells.[6]

IL20RB is linked with atherosclerosis and gastrointestinal diseases, although its specific roles are unknown.[6]

Glaucoma

IL20RB mRNA is expressed in retinal ganglion cells and optic nerves in rats. Mutations in the IL20RB gene are associated with glaucoma. The specific links between IL20RB and glaucoma are unknown, but IL20RB does not have a causative effect on the disease, instead contributing to an increased risk of the disease along with other factors, such as intraocular pressure.[5][8]

References
  1. GRCh38: Ensembl release 89: ENSG00000174564 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000044244 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rutz S, Wang X, Ouyang W (December 2014). "The IL-20 subfamily of cytokines--from host defence to tissue homeostasis". Nature Reviews. Immunology. 14 (12): 783–795. doi:10.1038/nri3766. PMID 25421700.
  6. Wegenka UM (October 2010). "IL-20: biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews. 21 (5): 353–363. doi:10.1016/j.cytogfr.2010.08.001. PMID 20864382.
  7. Kragstrup TW, Andersen T, Heftdal LD, Hvid M, Gerwien J, Sivakumar P, et al. (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9: 2226. doi:10.3389/fimmu.2018.02226. PMC 6167463. PMID 30319661.
  8. Wirtz MK, Keller KE (2016-01-20). "The Role of the IL-20 Subfamily in Glaucoma". Mediators of Inflammation. 2016: 4083735. doi:10.1155/2016/4083735. PMC 4745377. PMID 26903709.

Further reading
  • Overview of all the structural information available in the PDB for UniProt: Q6UXL0 (Interleukin-20 receptor subunit beta) at the PDBe-KB.
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