IL31RA

IL31RA
Identifiers
Aliases	IL31RA, CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R, interleukin 31 receptor A, zcytoR17
External IDs	OMIM: 609510 MGI: 2180511 HomoloGene: 51395 GeneCards: IL31RA
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	55,922,854 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	112,730,894 bp[2]
RNA expression pattern
	Top expressed in
	monocyte; ; thoracic aorta; ; ascending aorta; ; spinal ganglia; ; trigeminal ganglion; ; tibia; ; zone of skin; ; skin of limb; ; thymus; ; skin of abdomen;
	Top expressed in
	secondary oocyte; ; seminal vesicula; ; spermatid; ; morula; ; lip; ; zone of skin; ; uterus; ; skin of back; ; blood; ; mirror;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator activity; cytokine receptor activity; protein kinase binding; cytokine binding;
Cellular component	membrane; external side of plasma membrane; plasma membrane; synapse; cell junction; integral component of membrane; axon; intracellular anatomical structure; presynaptic membrane; cell projection; receptor complex;
Biological process	defense response; receptor signaling pathway via JAK-STAT; transmembrane receptor protein tyrosine kinase signaling pathway; cytokine-mediated signaling pathway; immune system process; defense response to other organism; negative regulation of macrophage activation; negative regulation of apoptotic process; acute inflammatory response to antigenic stimulus; monocyte differentiation; macrophage differentiation; MAPK cascade; positive regulation of transcription, DNA-templated; glandular epithelial cell differentiation; positive regulation of cell population proliferation; T-helper 2 cell cytokine production; homeostatic process; positive regulation of tyrosine phosphorylation of STAT protein;
	Sources:Amigo / QuickGO
Orthologs
	133396
	218624
	ENSG00000164509
	ENSMUSG00000050377
	Q8NI17
	Q8K5B1
NM_001242636; NM_001242637; NM_001242638; NM_001242639; NM_001297570;
	NM_001297572; NM_139017
	NM_139299
NP_001229565; NP_001229566; NP_001229567; NP_001229568; NP_001284499;
	NP_001284501; NP_620586
	NP_647460
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.[5][6][7]

IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004).[supplied by OMIM][7]

References

GRCh38: Ensembl release 89: ENSG00000164509 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000050377 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA (Jun 2004). "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice". Nat Immunol. 5 (7): 752–60. doi:10.1038/ni1084. PMID 15184896. S2CID 12442845.
Ghilardi N, Li J, Hongo JA, Yi S, Gurney A, de Sauvage FJ (May 2002). "A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5". J Biol Chem. 277 (19): 16831–6. doi:10.1074/jbc.M201140200. PMID 11877449.
"Entrez Gene: IL31RA interleukin 31 receptor A".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Diveu C, Lelièvre E, Perret D, et al. (2004). "GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor". J. Biol. Chem. 278 (50): 49850–9. doi:10.1074/jbc.M307286200. PMID 14504285.
Dreuw A, Radtke S, Pflanz S, et al. (2005). "Characterization of the signaling capacities of the novel gp130-like cytokine receptor". J. Biol. Chem. 279 (34): 36112–20. doi:10.1074/jbc.M401122200. PMID 15194700.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Diveu C, Lak-Hal AH, Froger J, et al. (2005). "Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling". Eur. Cytokine Netw. 15 (4): 291–302. PMID 15627637.
Bilsborough J, Leung DY, Maurer M, et al. (2006). "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis". J. Allergy Clin. Immunol. 117 (2): 418–25. doi:10.1016/j.jaci.2005.10.046. PMID 16461143.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164509 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050377 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15184896-5] Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA (Jun 2004). "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice". Nat Immunol. 5 (7): 752–60. doi:10.1038/ni1084. PMID 15184896. S2CID 12442845.

[pmid11877449-6] Ghilardi N, Li J, Hongo JA, Yi S, Gurney A, de Sauvage FJ (May 2002). "A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5". J Biol Chem. 277 (19): 16831–6. doi:10.1074/jbc.M201140200. PMID 11877449.

[entrez-7] "Entrez Gene: IL31RA interleukin 31 receptor A".

IL31RA

References

Further reading