IMPDH2

Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene.[5][6][7]

IMPDH2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIMPDH2, IMPD2, IMPDH-II, IMP (inosine 5'-monophosphate) dehydrogenase 2, inosine monophosphate dehydrogenase 2
External IDsOMIM: 146691 MGI: 109367 HomoloGene: 48919 GeneCards: IMPDH2
Orthologs
SpeciesHumanMouse
Entrez

3615

23918

Ensembl

ENSG00000178035

ENSMUSG00000062867

UniProt

P12268

P24547

RefSeq (mRNA)

NM_000884

NM_011830
NM_001378921

RefSeq (protein)

NP_000875

NP_035960
NP_001365850

Location (UCSC)Chr 3: 49.02 – 49.03 MbChr 9: 108.44 – 108.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. IMPDH2 catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate.[5] IMPDH2 has been identified as an intracellular target of the natural product sanglifehrin A[8]

Clinical significance

This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.[5]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000178035 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000062867 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: IMP (inosine monophosphate) dehydrogenase 2".
  6. Natsumeda Y, Ohno S, Kawasaki H, Konno Y, Weber G, Suzuki K (March 1990). "Two distinct cDNAs for human IMP dehydrogenase". J. Biol. Chem. 265 (9): 5292–5. doi:10.1016/S0021-9258(19)34120-1. PMID 1969416.
  7. Kost-Alimova MV, Glesne DA, Huberman E, Zelenin AV (1998). "Assignment1 of inosine '-monophosphate dehydrogenase type 2 (IMPDH2) to human chromosome band 3p21.2 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 145–6. doi:10.1159/000015088. PMID 9858805. S2CID 46764436.
  8. Pua KH, Stiles DT, Sowa ME, Verdine GL (10 January 2017). "IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex". Cell Rep. 18 (2): 432–442. doi:10.1016/j.celrep.2016.12.030. PMID 28076787.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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