INHA

Inhibin, alpha, also known as INHA, is a protein which in humans is encoded by the INHA gene.[5]

INHA
Identifiers
AliasesINHA, inhibin alpha subunit, inhibin subunit alpha
External IDsOMIM: 147380 MGI: 96569 HomoloGene: 1652 GeneCards: INHA
Orthologs
SpeciesHumanMouse
Entrez

3623

16322

Ensembl

ENSG00000123999

ENSMUSG00000032968

UniProt

P05111

Q04997

RefSeq (mRNA)

NM_002191

NM_010564
NM_001329843

RefSeq (protein)

NP_002182

NP_001316772
NP_034694

Location (UCSC)Chr 2: 219.57 – 219.58 MbChr 1: 75.48 – 75.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease.

However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000123999 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032968 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Burger HG, Igarashi M (April 1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology. 122 (4): 1701–2. doi:10.1210/endo-122-4-1701. PMID 3345731.
  6. "Entrez Gene: INHA inhibin, alpha".

Further reading


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