Idorsia

Idorsia is a Swiss pharmaceutical research company in Allschwil, near Basel, Switzerland.

Idorsia AG
TypePublic company
ISINCH0363463438
Industrypharmaceutical research
Founded2017
FounderJean-Paul Clozel, Martine Clozel
HeadquartersAllschwil,
Switzerland
Key people
Jean-Paul Clozel (CEO), Martine Clozel (Chief Scientific Officer), Guy Braunstein (Chief Medical Officer)
Productsclazosentan, daridorexant
Revenue7 million CHF (2021)
-122 million CHF (2021)
-105 million CHF (2021)
Number of employees
> 1200 (2022)
Websitehttp://www.idorsia.ch; http://www.idorsia.com

History

After Actelion was bought by Johnson & Johnson in 2017,[1] Idorsia was spun out into a new company and started operating on the same campus where Actelion was founded under the leadership of Actelion founders Jean-Paul Clozel Clozel as CEO and Martine Clozel as CSO. The company expects to be profitable in 2025.[2]

In July 2023 due to disappointing sales ramp-up of recently approved sleep drug Daridorexant coupled with disappointing trial results in both Clazosentan and Lucerestat, Idorsia announced layoffs of up to 500 staff of its 1200 total employees, to reduce cash burn at its Swiss headquarters by 50%.[3][4] The main shareholder Jean-Paul Clozel provided Idorsia with a private loan of CHF 75 Mio.[5]

In the same month, Idorsia sold its operating businesses in Japan and South Korea to the Japanese firm Sosei Heptares for CHF 400 million. This includes the rights to market clazosentan (Piviaz) and

daridorexant (Quviiq)in the Asia Pacific region excluding China, plus rights on two other treatments and up to five clinical-stage programs in Idorsia's pipeline.[6]

Products

Table current as of May 2, 2022, listing the drugs that have reached at least phase 3 trials.[7]

drugdisease, condition, remarksphase
DaridorexantInsomnia
First insomnia drug to improve both night-time symptoms and day-time function[8]		Approved in the United States and the EU[2]
Clazosentancerebral vasospasmApproved in Japan
LucerastatFabry diseasePhase 3 failed; research into other applications continuing
SelatogrelAcute mycardial infarctionPhase 3
  • Business data for Idorsia AG:

References
  1. "Johnson & Johnson Announces Completion of Acquisition of Actelion | Johnson & Johnson". Content Lab U.S. Retrieved 2023-08-21.
  2. "Idorsia-Medikament Quviviq erhält Zulassung in der EU" [Idorsia drug Quviviq gains approval in the EU] (in German). cash.ch. 2022-05-03. Retrieved 2022-05-03.
  3. Ltd, Idorsia Pharmaceuticals (2023-07-21). "Idorsia announces a cost reduction initiative to be implemented by the end of 2023". GlobeNewswire News Room. Retrieved 2023-08-21.
  4. Waldron, James (21 Jul 2023). "Sleepless nights for 500 Idorsia Staff".
  5. Serrar, Karim (2023-08-08). "Bio Revolution: Neu-Bewertung von Biotech-Aktien durch Biokonvergenz". Schweizer Aktien. Retrieved 2023-08-31.
  6. Smith, Jonathan (2023-07-20). "Idorsia sells APAC businesses to Sosei Heptares for $466 million". OUtsourcing Pharma. Retrieved 2023-09-27.
  7. "Idorsia Company Profile" (PDF). Idorsia. Retrieved 2022-05-02.
  8. "The Lancet Neurology reports impact of daridorexant on both nighttime symptoms and daytime functioning in adults with insomnia". 2022-02-22. Retrieved 2022-05-02.
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