Inositol-pentakisphosphate 2-kinase
In enzymology, an inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) is an enzyme that catalyzes the chemical reaction
- ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate ADP + 1D-myo-inositol hexakisphosphate
| Inositol-pentakisphosphate 2-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.158 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 1,3,4,5,6-pentakisphosphate, whereas its two products are ADP and 1D-myo-inositol hexakisphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase. Other names in common use include IP5 2-kinase, Gsl1p, Ipk1p, inositol polyphosphate kinase, inositol 1,3,4,5,6-pentakisphosphate 2-kinase, and Ins(1,3,4,5,6)P5 2-kinase.
References
- York JD, Odom AR, Murphy R, Ives EB, Wente SR (1999). "A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export". Science. 285 (5424): 96–100. doi:10.1126/science.285.5424.96. PMID 10390371.
- Phillippy BQ, Ullah AH, Ehrlich KC (1994). "Purification and some properties of inositol 1,3,4,5,6-Pentakisphosphate 2-kinase from immature soybean seeds". J. Biol. Chem. 269 (45): 28393–9. PMID 7961779.
- Phillippy BQ, Ullah AH, Ehrlich KC (1997). "Additions and corrections to Purification and some properties of inositol 1,3,4,5,6-pentakisphosphate 2-kinase from immature soybean seeds". J. Biol. Chem. 270 (13): 7782. doi:10.1074/jbc.270.13.7782.
- Ongusaha PP, Hughes PJ, Davey J, Michell RH. "Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation". Biochem. J. 335: 671–9. PMC 1219831. PMID 9794810.
- Miller AL, Suntharalingam M, Johnson SL, Audhya A, Emr SD, Wente SR (2004). "Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway". J. Biol. Chem. 279 (49): 51022–32. doi:10.1074/jbc.M409394200. PMID 15459192.
- Stevenson-Paulik J, Odom AR, York JD (2002). "Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases". J. Biol. Chem. 277 (45): 42711–8. doi:10.1074/jbc.M209112200. PMID 12226109.
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