Inositol 3-kinase

In enzymology, an inositol 3-kinase (EC 2.7.1.64) is an enzyme that catalyzes the chemical reaction

ATP + myo-inositol ADP + 1D-myo-inositol 3-phosphate
inositol 3-kinase
Identifiers
EC no.2.7.1.64
CAS no.37278-07-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are ATP and myo-inositol, whereas its two products are ADP and 1D-myo-inositol 3-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:myo-inositol 1-phosphotransferase. Other names in common use include inositol-1-kinase (phosphorylating), myoinositol kinase, and myo-inositol 1-kinase. This enzyme participates in inositol phosphate metabolism.

References

    • English PD, Dietz M, Albersheim P (1966). "Myoinositol kinase: partial purification and identification of product". Science. 151 (3707): 198–199. doi:10.1126/science.151.3707.198.
    • and Loewus FA; Sasaki, K.; Leavitt, A. L.; Munsell, L.; Sherman, W. R.; Loewus, F. A. (1982). "Enantiomeric form of myo-inositol-1-phosphate produced by myo-inositol-1-phosphate synthase and myoinositol kinase in higher-plants". Plant Physiol. 70 (6): 1661–1663. doi:10.1104/pp.70.6.1661. PMC 1065950. PMID 16662739.
    • Stephens LR, Kay RR, Irvine RF (1990). "A myo-inositol D-3 hydroxykinase activity in Dictyostelium". Biochem. J. 272 (1): 201–10. PMC 1149677. PMID 2176081.


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