Inter-alpha-trypsin inhibitor

Inter-alpha-trypsin inhibitors (IαI) are plasma proteins consisting of three of four heavy chains selected from the group ITIH1, ITIH2, ITIH3, ITIH4 and one light chain selected from the group AMBP or SPINT2.[1] They function as protease inhibitors.

IαI form complexes with hyaluronan (HA), generating a serum-derived hyaluronan-associated protein (SHAP)-HA complex. The SHAP-HA complex is found in very high concentration in rheumatoid arthritic synovial fluid suggesting it has a role in the inflammatory response.[1]

References

Zhuo L, Hascall VC, Kimata K (September 2004). "Inter-alpha-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein complex". J. Biol. Chem. 279 (37): 38079–82. doi:10.1074/jbc.R300039200. PMID 15151994.

External links

Inter-alpha-inhibitor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[pmid15151994-1] Zhuo L, Hascall VC, Kimata K (September 2004). "Inter-alpha-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein complex". J. Biol. Chem. 279 (37): 38079–82. doi:10.1074/jbc.R300039200. PMID 15151994.