Interstate 95 in Georgia

In 1965, I-95 was proposed from the Florida state line to SR 251 near Darien. It was under construction from there to SR 99 near Crescent. It was proposed from there to the South Carolina state line.[7][8] In 1966, it was under construction from its southern interchange with SR 99 to just north of SR 131 in South Newport.[8][9] In 1967, it was under construction just north of South Newport. It was under construction from Richmond Hill to I-16 near Savannah.[9][2] In 1968, it was under construction from the Florida state line to SR 40 in Kingsland. It was also under construction from its southern interchange with SR 99 to SR 251 near Darien. It was open as I-95 from SR 251 to its northern interchange with SR 99 in Eulonia. It was under construction from Eulonia to US 17/SR 25 north of South Newport.[2][3]

In 1970, the highway was under construction from the Florida state line to just southeast of Woodbine. It was also under construction from US 25/US 341/SR 27 near Brunswick to SR 251 near Darien. It also had an under construction from Eulonia to I-16.[10][11] In 1971, it was under construction from the Florida state line to northeast of White Oak and also between the US 17/SR 25 interchanges north of South Newport and in Richmond Hill.[11][12] In 1972, it was open from the Florida state line to SR 40 in Kingsland. It was under construction from Kingsland to northeast of White Oak. It was under construction from east of Waverly to US 25/US 341/SR 27 near Brunswick. It was open from there to US 17/SR 25 north of South Newport. It was open from Richmond Hill to I-16. It was under construction from just west of the South Carolina state line to the line.[12][13] In 1973, it was open from the Florida state line to southeast of Woodbine. It was under construction from there to near Brunswick and from I-16 to the South Carolina state line.[13][14] In 1974, the highway was open from the Brunswick to SR 38 southeast of Midway.[14][15] In 1976, it was open from the Florida state line to US 17/US 84/SR 25/SR 50 southeast of Brunswick. It was open from US 25/US 341/SR 27 near Brunswick to I-16.[16][17] In 1977, it was open for its entire length.[17][18]

In 1998, the Georgia State Senate passed a resolution to designate the portion of I-95 between the Ogeechee River (Bryan–Chatham county line) north to the Savannah River in the Savannah metropolitan area as the Tom Coleman Highway, in honor of Tom Coleman, a Democrat who served as state senator from 1981 to 1995.[19]

Until 2000, the state of Georgia used the sequential interchange numbering system on all of its Interstate Highways. The first exit on each highway would begin with the number 1 and increase numerically with each exit. In 2000, the Georgia Department of Transportation switched to a mileage-based exit system, in which the exit number corresponded to the nearest milepost.[20][21]

Construction to widen I-95 from two to three lanes started with the Chatham County segment in 1989, with the other county segments done in phases, with the project completed throughout Georgia on December 10, 2010.

Interstate 95 Business (I-95 Bus.) for Darien begins at exit 42 on I-95 and travels concurrent with SR 99. I-95 Bus. and SR 99 then join US 17/SR 25 (Ocean Highway; Altamaha Historic Scenic Byway), and the four highways enter Darien. There, SR 99 splits off, while I-95 Bus. continues following US 17/SR 25 to an intersection with the southern terminus of SR 251 just north of Darien. Here, I-95 Bus. turns onto SR 251 and follows it until it reunites with I-95 at its northern terminus at exit 49. I-95 Bus. is only signed on I-95 at each exit (northbound at the southern terminus and southbound at the northern terminus) and is not signed on any of its constituent highways.

County	Location	mi[23]	km	Destinations	Notes
Glynn	​	0.0– 0.3	0.0– 0.48	I-95 / SR 99 south – Brunswick, Savannah, Sterling	Southern end of SR 99 concurrency; southern terminus; I-95 exit 42
	​	1.4	2.3	US 17 south / SR 25 south (Altamaha Historic Scenic Byway) – Hofwyl–Broadfield Plantation State Historic Site	Southern end of US 17/SR 25 concurrency
Altamaha River		2.9 3.4	4.7 5.5	Harold James Friedman Memorial Bridge
McIntosh	Darien	6.3	10.1	SR 99 north (Adams Street) / Third Street West west – Ridgeville, Fort King George, Sapelo Island	Northern end of SR 99 concurrency; eastern terminus of Third Street West
	​	7.4	11.9	US 17 north (SR 25 north) / SR 251 begins – Savannah	Northern end of US 17/SR 25 concurrency; southern end of SR 251 concurrency; southern terminus of SR 251; I-95 Bus. turns left onto SR 251.
	​	8.5– 8.7	13.7– 14.0	I-95 / SR 251 north – Brunswick, Savannah, Townsend	Northern end of SR 251 concurrency; northern terminus; I-95 exit 49
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

Former Interstate 95 Business (I-95 Bus.) for Brunswick used to serve Brunswick and the Golden Isles of Georgia between exits 29 and 38 (former exits 6 and 8). It was concurrent with US 17/SR 25 but no longer exists. The highway returned to I-95 via SR 25 Spur.