Isoeugenol synthase

Isoeugenol synthase (EC 1.1.1.319, IGS1, t-anol/isoeugenol synthase 1) is an enzyme with systematic name eugenol:NADP+ oxidoreductase (coniferyl acetate reducing).[1][2][3] This enzyme catalyses the following chemical reaction.[4]

isoeugenol + acetate + NADP+ coniferyl acetate + NADPH + H+
Isoeugenol synthase
Identifiers
EC no.1.1.1.319
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme acts in the reverse direction.

Dexter et al., 2007 finds that the substrate is coniferyl acetate.[5]

References
  1. Koeduka T, Fridman E, Gang DR, Vassão DG, Jackson BL, Kish CM, Orlova I, Spassova SM, Lewis NG, Noel JP, Baiga TJ, Dudareva N, Pichersky E (June 2006). "Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester". Proceedings of the National Academy of Sciences of the United States of America. 103 (26): 10128–33. doi:10.1073/pnas.0603732103. PMC 1502517. PMID 16782809.
  2. Koeduka T, Louie GV, Orlova I, Kish CM, Ibdah M, Wilkerson CG, Bowman ME, Baiga TJ, Noel JP, Dudareva N, Pichersky E (May 2008). "The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages". The Plant Journal. 54 (3): 362–74. doi:10.1111/j.1365-313X.2008.03412.x. PMC 2741023. PMID 18208524.
  3. Koeduka T, Baiga TJ, Noel JP, Pichersky E (January 2009). "Biosynthesis of t-anethole in anise: characterization of t-anol/isoeugenol synthase and an O-methyltransferase specific for a C7-C8 propenyl side chain". Plant Physiology. 149 (1): 384–94. doi:10.1104/pp.108.128066. PMC 2613694. PMID 18987218.
  4. Gupta AK, Schauvinhold I, Pichersky E, Schiestl FP (December 2014). "Eugenol synthase genes in floral scent variation in Gymnadenia species" (PDF). Functional & Integrative Genomics. 14 (4): 779–88. doi:10.1007/s10142-014-0397-9. hdl:20.500.11850/91540. PMID 25239559. S2CID 17207240.
  5. Vogt, Thomas (2010). "Phenylpropanoid Biosynthesis". Molecular Plant. 3 (1): 2–20. doi:10.1093/mp/ssp106. PMID 20035037. S2CID 39503278.
    This review cites this research.
    Dexter, Richard; Qualley, Anthony; Kish, Christine M.; Ma, Choong Je; Koeduka, Takao; Nagegowda, Dinesh A.; Dudareva, Natalia; Pichersky, Eran; Clark, David (2006-12-07). "Characterization of a petunia acetyltransferase involved in the biosynthesis of the floral volatile isoeugenol". The Plant Journal. 49 (2): 265–275. doi:10.1111/j.1365-313x.2006.02954.x. hdl:2027.42/74478. PMID 17241449. S2CID 6714361.
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