Jean Lud Cadet
Jean Lud Cadet is a Haitian-American psychiatrist at the National Institute on Drug Abuse (NIDA), where he serves as National Institutes of Health Chief of the Molecular Neuropsychiatry Research Branch. His research considers the genetic, epigenetic and cellular bases of substance abuse. In 2020 he was selected as one of Cell Press' Most Inspiring Black Scientists in America.[1]
Jean Lud Cadet | |
|---|---|
 Cadet's official National Institute on Drug Abuse photo, 2017 | |
| Born | |
| Alma mater | Columbia University Collège Notre-Dame |
| Scientific career | |
| Institutions | National Institute on Drug Abuse National Institutes of Health Mount Sinai Health System Columbia University |
Early life and education
Cadet is from Haiti.[2] He attended the Collège Notre-Dame for high school. After graduating high school, Cadet moved to New York City in 1970, where he joined Columbia University to complete a degree in medicine. He was a psychiatry resident at both Columbia University and in the Mount Sinai Health System.[2]
Research and career
In 1992 Cadet moved to the National Institute on Drug Abuse (NIDA), where he serves as National Institutes of Health Chief of the Molecular Neuropsychiatry Research Branch.[2][3] His early research considered the effects of drugs on human memory.[4] He has shown that the molecular networks within the brain are impacted by the acute administration of addictive substances. In particular, Cadet has considered the cellular mechanisms that underpin addiction of psychostimulants.[3] Cadet has looked at the influence of addictive substances on the expression of immediate early gene (IEGs), and shown that IEGs can be induced within minutes of activation.[5]
He has studied self-administration of methamphetamine,[6] and shown that in striatal dopaminergic systems it is accompanied with markers of toxicity.[3] This indicates that dopamine activates neurodegenerative processes within the brain, via the upregulation of neurotrophic factors and downregulation of glutamatergic systems.
Select publications
- Bolla, K. I.; Brown, K.; Eldreth, D.; Tate, K.; Cadet, J. L. (2002-11-12). "Dose-related neurocognitive effects of marijuana use". Neurology. 59 (9): 1337–1343. doi:10.1212/01.WNL.0000031422.66442.49. ISSN 0028-3878. PMID 12427880. S2CID 11525660.
- Bolla, K. I; Eldreth, D. A; London, E. D; Kiehl, K. A; Mouratidis, M; Contoreggi, C; Matochik, J. A; Kurian, V; Cadet, J. L; Kimes, A. S; Funderburk, F. R (2003-07-01). "Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task". NeuroImage. 19 (3): 1085–1094. doi:10.1016/S1053-8119(03)00113-7. ISSN 1053-8119. PMC 2767245. PMID 12880834.
- Cadet, Jean Lud; Brannock, Christie (1998-02-01). "Invited Review Free radicals and the pathobiology of brain dopamine systems". Neurochemistry International. 32 (2): 117–131. doi:10.1016/S0197-0186(97)00031-4. ISSN 0197-0186. PMID 9542724. S2CID 24866888.
References
- Hinton, Antentor O. Jr. "100 more inspiring Black scientists in America". crosstalk.cell.com. Retrieved 2020-11-23.
- "Faculty Bio – Jean Lud Cadet". neurosciencecme.com. Retrieved 2020-09-26.
- "NIDA IRP - Jean Lud Cadet, M.D." NIDA IRP. Retrieved 2020-09-26.
- "NIDA Marks 25 Years of Progress In Drug Abuse Research". archives.drugabuse.gov. 1999-04-01. Retrieved 2020-09-26.
- "Expression of immediate early genes in brain reward circuitries: Differential regulation by psychostimulant and opioid drugs". NIDA IRP. 2019-01-11. Retrieved 2020-09-26.
- Forum, Addiction Policy (2020-09-18). "Ask the Expert: How do you treat methamphetamine use disorder". APF. Retrieved 2020-09-26.
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