Joachim Messing

Jo Messing was a pharmacist by training, but specialized in molecular biology during his PhD-research at the LM University of Munich and the Max-Planck Institute of Biochemistry.

In the late seventies and early eighties, Jo Messing and his colleagues developed the shotgun DNA sequencing method with single and paired synthetic universal primers. The method is based on fragmenting DNA into small sizes, purifying them by cloning, and defining the start of sequencing with a short oligonucleotide.[9][10] Because fragmentation produces overlapping fragments, sequences can be concatenated by overlapping sequence information,[11] thereby reconstructing contiguous sequences (contigs), which was first exemplified by the complete structure of a plant DNA virus.[12] His cloning vectors were also used to develop the method for oligonucleotide site-directed mutagenesis.[13] DNA cloning, shotgun sequencing and site-directed mutagenesis became widely used to sequence large DNA molecules like human chromosomes and to engineer genes and proteins. These methods are freely available, have been the cornerstone of the biotechnology industry and are cited in many patents.

At Rutgers, his plant genetics initiatives were directed towards the evolution of plant chromosomes and gene duplication. He also did research in non-Mendelian inheritance. Applied research in these genomic sequences permitted his laboratory to study the organization and evolution of the genes that control the supply of proteins for nutrition and as sources of biofuel. Projects with maize focused on upgrading the nutritional value of corn by genetically modifying corn to make methionine and lysine in the seeds, two essential amino acids that people and livestock need in their diet. Investigating the genetic properties of sorghum led to a natural sorghum variant with increased sugar in the stem allows the plant to be used for both biofuel and feed. Most recent initiatives investigating the properties of spirodela (duckweed) led to its discovery as an alternative bio-energy source.[14]

• 1968: B.S. in Pharmacy, Düsseldorf, Germany
• 1971: M.S. in Pharmacy, Free University of Berlin, Berlin
• 1975: Dr. rer. nat. in Biochemistry/Pharmacy Ludwig-Maximilians University, Munich, Germany[15]

• 1975–1978: Research Fellow, Max Planck Institute of Biochemistry, Munich, Germany
• 1978–1980: Research Associate in Bacteriology, University of California, Davis, CA
• 1980–1982: Assistant Professor of Biochemistry, University of Minnesota, St. Paul, MN
• 1982–1984: Associate Professor of Biochemistry, University of Minnesota, St. Paul, MN
• 1984–1985: Professor of Biochemistry, University of Minnesota, St. Paul, MN
• 1985–2019: University Professor of Molecular Biology, Rutgers University
• 1988–2019: Director, Waksman Institute, Rutgers University

• 1981-1990 World's most-cited scientist[16]
• 1985-1986 The most cited 1985 paper in the life sciences[17]
• 2002 Fellow of the American Association for the Advancement of Science[18]
• 2004 United States Secretary of Agriculture Honor Award for (US Rice Genome)[19]
• 2007 Member of the National Academy of Sciences Leopoldina (Germany)[20]
• 2009 Inaugural Chair of the Selman Waksman Endowed Chair in Molecular Genetics at Rutgers University[21]
• 2013 Wolf Prize in Agriculture[22]
• 2014 Elected to the 100 Most Influential People in New Jersey in Food Category[23]
• 2014 Promega Biotechnology Research Award of American Society for Microbiology[24]
• 2015 Fellow of American Academy of Microbiology[25]
• 2015 Member of National Academy of Sciences[26]
• 2016 Rutgers University created Joachim Messing Endowed Chair in Molecular Genetics[27]
• 2016 Member of American Academy of Arts and Sciences[28]
• Recognized as a Pioneer Member of the American Society of Plant Biologists. [29]

• Thinking Big, Geneticist solves problems with biotechnology, I am NJ by the Star Ledger, January 2007