Jonathan Weissman

Jonathan S. Weissman is the Landon T. Clay Professor of Biology at the Massachusetts Institute of Technology, a member of the Whitehead Institute, and a Howard Hughes Medical Institute Investigator. From 1996 to 2020, he was a faculty member in the department of cellular molecular pharmacology at the University of California, San Francisco.

Jonathan S. Weissman
NationalityAmerican
Alma materHarvard University, MIT, Yale University
Known forRibosome profiling Protein folding
Awards
Scientific career
FieldsBiochemistry Biophysics
InstitutionsMIT

UCSF

HHMI
Doctoral advisorPeter Kim
Other academic advisorsArthur Horwich

Education

He earned his B.A. in physics from Harvard College (1988) and his Ph.D. in physics (1993) from MIT working with Peter Kim. There, he started his studies on protein folding examining Bovine pancreatic trypsin inhibitor (BPTI).[1]

He was a postdoctoral fellow at Yale University (1993–1996), where he worked with Arthur Horwich studying the mechanism of GroEL.[2][3]

Career

Weissman's research team studies how cells ensure that proteins fold into their correct shape, as well as the role of protein misfolding in disease and normal physiology. The team also develops experimental and analytical approaches for exploring the organizational principles of biological systems and globally monitoring protein translation through ribosome profiling. A broad goal of his work is to bridge large-scale approaches and in depth mechanistic investigations to reveal the information encoded within genomes.[4][5][6]

Weissman has been a member of the National Academy of Sciences since 2009.

References
  1. Hoffman, M (Sep 20, 1991). "Straightening out the protein folding puzzle". Science. 253 (5026): 1357–8. Bibcode:1991Sci...253.1357H. doi:10.1126/science.1896845. PMID 1896845. S2CID 38632703.
  2. Weissman, JS; Hohl, CM; Kovalenko, O; Kashi, Y; Chen, S; Braig, K; Saibil, HR; Fenton, WA; Horwich, AL (Nov 17, 1995). "Mechanism of GroEL action: productive release of polypeptide from a sequestered position under GroES". Cell. 83 (4): 577–87. doi:10.1016/0092-8674(95)90098-5. PMID 7585961. S2CID 17839893.
  3. Weissman, Jonathan S.; O'Shea, Erin K. (1 January 2009). "2004 Irving Sigal Young Investigator Award". Protein Science. 13 (12): 3333–3335. doi:10.1110/ps.041134604. PMC 2287319. PMID 15557272.
  4. "New Technique Focuses on Transcription". HHMI. 20 January 2011. Retrieved 14 February 2013.
  5. Ingolia, Nicholas T.; Lareau, Liana F.; Weissman, Jonathan S. (1 November 2011). "Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes". Cell. 147 (4): 789–802. doi:10.1016/j.cell.2011.10.002. PMC 3225288. PMID 22056041.
  6. "Jonathan S. Weissman". HHMI. Retrieved 14 February 2013.
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