Karen Canfell

Karen Canfell is an Australian epidemiologist and cancer researcher.

After being awarded a D.Phil. from Oxford in 2004 with a thesis entitled Use of hormone replacement therapy as a potential co-factor in the neoplastic progression of HPV-related cervical disease,[1] Canfell returned to Australia to work for the Cancer Council in Sydney where she continued to work on cervical cancer in particular[2][3][4] and all its ramifications, as well as the epidemiology of breast,[5][6] and other cancers.[7][8][9]

With the advent of HPV vaccines and the mass HPV vaccination programs in Australia for girls (starting in 2007) and boys (starting in 2013) to prevent HPV infection, her interests turned to monitoring the effects of such programs,[10] appropriate screening for cervical cancer in Australia[11] and other countries.[12][13][14] A major focus has been how to do this effectively in developing and low-income countries[15][16][17] as well as in high-income countries.[18][19]

Together with her team, her work was fundamental in Australia making the 2017 transition of their national cervical screening program from cytology (pap smears) to a 5-yearly HPV DNA-based screening,[20][21] and her work both with respect to other countries and in Australia[22] means that Australia is on track to eliminate cervical cancer by 2028.[23]

Career

Canfell worked for the NSW Cancer Council from approximately 2004 to 2011.[24][7] By 2012 Canfell was affiliated with both the Cancer Research Division of the Cancer Council and the School of Public Health at the University of Sydney.[16][25] By 2013 she was a professor at UNSW (Prince of Wales Clinical School)[18] and continued there until at least 2019.[26]

From approximately 2020 she has been the director of The Daffodil Centre at the University of Sydney (a joint venture with the Cancer Council).[20] She is a co-leader of the World Health Organisation (WHO) Cervical Cancer Elimination Modelling Consortium.[26][20]

Awards

In 2019 she became a Fellow of the Australian Academy of Health and Medical Science,[27] and in 2020 won an Elizabeth Blackburn Investigator grant award for leadership in Health Services Research.[20] In 2015 she won the NHMRC National Award for Research Excellence and was also nominated that year as a Woman of Influence by Westpac and the Australian Financial Review.[28]

In 2021 she was invited to give the prestigious Richard Doll Seminar at Oxford where she spoke as co-leader of the World Health Organisation (WHO) Cervical Cancer Elimination Modelling Consortium on the topic of the WHO's strategy for the elimination of cervical cancer[29] (The road to cervical cancer elimination).[30][31]

References
  1. Karen Canfell; Karen Canfell (2004), Use of hormone replacement therapy as a potential co-factor in the neoplastic progression of HPV-related cervical disease, Wikidata Q111598767
  2. Karen Canfell; Valerie Beral; Jane Green; Rebecca Cameron; Krys Baker; Anna Brown (1 January 2006). "The agreement between self-reported cervical smear abnormalities and screening programme records". Journal of Medical Screening. 13 (2): 72–75. doi:10.1258/096914106777589687. ISSN 0969-1413. PMID 16792828. Wikidata Q50725908.
  3. Karen Canfell; Freddy Sitas; Valerie Beral (1 November 2006). "Cervical cancer in Australia and the United Kingdom: comparison of screening policy and uptake, and cancer incidence and mortality". Medical Journal of Australia. 185 (9): 482–486. doi:10.5694/J.1326-5377.2006.TB00661.X. ISSN 0025-729X. PMID 17137451. Wikidata Q44359122.
  4. Karen Canfell; Yoon Jung Kang; Mark Clements; Aye Myat Moa; Valerie Beral (1 January 2008). "Normal endometrial cells in cervical cytology: systematic review of prevalence and relation to significant endometrial pathology". Journal of Medical Screening. 15 (4): 188–198. doi:10.1258/JMS.2008.008069. ISSN 0969-1413. PMID 19106259. Wikidata Q37357523.
  5. Karen Canfell; Emily Banks; Aye M Moa; Valerie Beral (1 June 2008). "Decrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in Australia". Medical Journal of Australia. 188 (11): 641–644. ISSN 0025-729X. PMID 18513172. Wikidata Q46237149.
  6. Karen Canfell; Emily Banks; Mark Clements; Yoon Jung Kang; Aye Moa; Bruce Armstrong; Valerie Beral (15 February 2009). "Sustained lower rates of HRT prescribing and breast cancer incidence in Australia since 2003". Breast Cancer Research and Treatment. 117 (3): 671–673. doi:10.1007/S10549-009-0331-3. ISSN 0167-6806. PMID 19219631. Wikidata Q83357977.
  7. Ju-Fang Shi; Karen Canfell; Jie-Bin Lew; You-Lin Qiao (10 June 2011). "The burden of cervical cancer in China: synthesis of the evidence". International Journal of Cancer. 130 (3): 641–652. doi:10.1002/IJC.26042. ISSN 0020-7136. PMID 21387308. Wikidata Q37851067.
  8. Freddy Sitas; Alison Gibberd; Clare Kahn; et al. (30 October 2013). "Cancer incidence and mortality in people aged less than 75 years: changes in Australia over the period 1987-2007". Cancer Epidemiology. 37 (6): 780–787. doi:10.1016/J.CANEP.2013.09.010. ISSN 1877-7821. PMID 24183782. Wikidata Q51188262.
  9. Marjolein J E Greuter; Xiang-Ming Xu; Jie-Bin Lew; Evelien Dekker; Ernst J Kuipers; Karen Canfell; Gerrit A Meijer; Veerle M. Coupé (31 October 2013). "Modeling the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA)". Risk Analysis. 34 (5): 889–910. doi:10.1111/RISA.12137. ISSN 1539-6924. PMID 24172539. Wikidata Q86613223.
  10. Karen Canfell (24 March 2010). "Monitoring HPV vaccination programmes". The BMJ. 340: c1666. doi:10.1136/BMJ.C1666. ISSN 0959-8138. PMID 20335330. Wikidata Q83900358.
  11. Prudence Creighton; Jie-Bin Lew; Mark Clements; Megan Smith; Kirsten Howard; Suzanne Dyer; Sarah Lord; Karen Canfell (26 November 2010). "Cervical cancer screening in Australia: modelled evaluation of the impact of changing the recommended interval from two to three years". BMC Public Health. 10: 734. doi:10.1186/1471-2458-10-734. ISSN 1471-2458. PMC 3001736. PMID 21110881. Wikidata Q33756785.
  12. Karen Canfell (1 September 2010). "Models of cervical screening in the era of human papillomavirus vaccination". Sexual Health. 7 (3): 359–367. doi:10.1071/SH10016. ISSN 1448-5028. PMID 20719228. Wikidata Q37780816.
  13. Karen Canfell; Ju-Fang Shi; Jie-Bin Lew; et al. (4 January 2011). "Prevention of cervical cancer in rural China: evaluation of HPV vaccination and primary HPV screening strategies". Vaccine. 29 (13): 2487–2494. doi:10.1016/J.VACCINE.2010.12.085. ISSN 0264-410X. PMID 21211586. Wikidata Q58299168.
  14. Ju-Fang Shi; Karen Canfell; Jie-Bin Lew; et al. (13 June 2011). "Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study". BMC Cancer. 11: 239. doi:10.1186/1471-2407-11-239. ISSN 1471-2407. PMC 3141766. PMID 21668946. Wikidata Q33930993.
  15. Margaret Urban; Emily Banks; Sam Egger; Karen Canfell; Dianne O'Connell; Valerie Beral; Freddy Sitas (6 March 2012). "Injectable and oral contraceptive use and cancers of the breast, cervix, ovary, and endometrium in black South African women: case-control study". PLOS MEDICINE. 9 (3): e1001182. doi:10.1371/JOURNAL.PMED.1001182. ISSN 1549-1277. PMC 3295825. PMID 22412354. Wikidata Q34192784.
  16. Ju-Fang Shi; Jun-Feng Chen; Karen Canfell; et al. (24 May 2012). "Estimation of the costs of cervical cancer screening, diagnosis and treatment in rural Shanxi Province, China: a micro-costing study". BMC Health Services Research. 12: 123. doi:10.1186/1472-6963-12-123. ISSN 1472-6963. PMC 3461448. PMID 22624619. Wikidata Q34280370.
  17. Karen Canfell; Jane J Kim; Marc Brisson; et al. (30 January 2020). "Mortality impact of achieving WHO cervical cancer elimination targets: a comparative modelling analysis in 78 low-income and lower-middle-income countries". The Lancet. 395 (10224): 591–603. doi:10.1016/S0140-6736(20)30157-4. ISSN 0140-6736. PMC 7043006. PMID 32007142. Wikidata Q89481201.
  18. Leonardo Simonella; Karen Canfell (6 July 2013). "The impact of a two- versus three-yearly cervical screening interval recommendation on cervical cancer incidence and mortality: an analysis of trends in Australia, New Zealand, and England". Cancer Causes & Control. 24 (9): 1727–1736. doi:10.1007/S10552-013-0250-9. ISSN 0957-5243. PMID 23832659. Wikidata Q87055586.
  19. Karen Canfell; Harrell Chesson; Shalini L Kulasingam; Johannes Berkhof; Mireia Diaz; Jane J Kim (1 November 2012). "Modeling preventative strategies against human papillomavirus-related disease in developed countries". Vaccine. 30 Suppl 5: F157-67. doi:10.1016/J.VACCINE.2012.06.091. ISSN 0264-410X. PMC 3783354. PMID 23199959. Wikidata Q37198208.
  20. "2020 Research Excellence Awards | NHMRC". www.nhmrc.gov.au. Retrieved 14 April 2022.
  21. "Professor Karen Canfell - C4 – Cervical Cancer Control". Retrieved 16 April 2022.
  22. Michaela Hall; Kate Simms; Jie-Bin Lew; Megan Smith; Julia Ml Brotherton; Marion Saville; Ian Frazer; Karen Canfell (2 October 2018). "The projected timeframe until cervical cancer elimination in Australia: a modelling study". Lancet Public Health. 4 (1): e19–e27. doi:10.1016/S2468-2667(18)30183-X. ISSN 2468-2667. PMID 30291040. Wikidata Q57058899.
  23. "Australia is on track to beat the world in eliminating cervical cancer". Australian Financial Review. 31 March 2021. Retrieved 14 April 2022.
  24. Usha Salagame; Karen Canfell; Emily Banks (1 May 2011). "An epidemiological overview of the relationship between hormone replacement therapy and breast cancer". Expert review of endocrinology & metabolism. 6 (3): 397–409. doi:10.1586/EEM.11.31. ISSN 1744-6651. PMID 30754116. Wikidata Q91504681.
  25. Nayyereh Aminisani; Bruce K Armstrong; Sam Egger; Karen Canfell (23 October 2012). "Impact of organised cervical screening on cervical cancer incidence and mortality in migrant women in Australia". BMC Cancer. 12: 491. doi:10.1186/1471-2407-12-491. ISSN 1471-2407. PMC 3573959. PMID 23092207. Wikidata Q34455506.
  26. "Professor Karen Canfell". research.unsw.edu.au. Retrieved 15 April 2022.
  27. "Academy elects new Fellows and discusses global pandemic threat at annual meeting". AAHMS - Australian Academy of Health and Medical Sciences. 9 October 2019. Retrieved 14 April 2022.
  28. "Karen Canfell". The Conversation. Retrieved 16 April 2022.
  29. Ophira Ginsburg; Partha Basu; Sharon Kapambwe; Karen Canfell (February 2021). "Eliminating cervical cancer in the COVID-19 era" (PDF). Nature Cancer. 2 (2): 133–134. doi:10.1038/S43018-021-00178-9. ISSN 2662-1347. Wikidata Q111610848.
  30. "Richard Doll Seminar 2021: The road to cervical cancer elimination (Karen Canfell)". YouTube.
  31. "Richard Doll Seminar". Retrieved 14 April 2022.
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