K. C. Nicolaou

Kyriacos Costa Nicolaou (Greek: Κυριάκος Κ. Νικολάου; born July 5, 1946) is a Cypriot-American chemist known for his research in the area of natural products total synthesis. He is currently Harry C. and Olga K. Wiess Professor of Chemistry at Rice University, having previously held academic positions at The Scripps Research Institute/UC San Diego and the University of Pennsylvania.

K. C. Nicolaou
BornJuly 5, 1946 (1946-07-05) (age 77)
Karavas, Cyprus
Alma materUniversity College London
Known forTotal synthesis
Nicolaou Taxol total synthesis
Corey–Nicolaou macrolactonization
AwardsErnest Guenther Award (1996)
Wolf Prize in Chemistry (2016)
Scientific career
FieldsChemistry
InstitutionsRice University

Scripps Research Institute
University of California, San Diego
University of Pennsylvania

ICES A*STAR
Doctoral studentsTushar Kanti Chakraborty
Other notable studentsPhil Baran
Govindasamy Mugesh

Biography

K. C. Nicolaou was born on July 5, 1946, in Karavas, Cyprus where he grew up and went to school until the age of 18. In 1964, he went to England where he spent two years learning English and preparing to enter University. He studied chemistry at the University of London (B.Sc., 1969, Bedford College; Ph.D. 1972, University College London, with Professors F. Sondheimer and P. J. Garratt). In 1972, he moved to the United States and, after postdoctoral appointments at Columbia University (1972–1973, Professor T. J. Katz) and Harvard University (1973–1976, Professor E. J. Corey), he joined the faculty at the University of Pennsylvania where he became the Rhodes-Thompson Professor of Chemistry. While at Penn, he won the prestigious Sloan Fellowship.[1]

In 1989, he relocated to San Diego, where he took up a joint appointment at the University of California, San Diego, where he served as Professor of Chemistry, and The Scripps Research Institute, where he was Darlene Shiley Professor of Chemistry and Chairman of the Department of Chemistry. In 1996, he was appointed Aline W. and L.S. Skaggs Professor of Chemical Biology in The Skaggs Institute for Chemical Biology, The Scripps Research Institute. From 2005 to 2011, he directed Chemical Synthesis Laboratory @ ICES-A*STAR, Singapore. In 2013, Nicolaou moved to Rice University.

The Nicolaou group is active in the field of organic chemistry with research interests in methodology development and total synthesis. He is responsible for the synthesis of many complex molecules found in nature, such as Taxol and vancomycin. His group's route to Taxol, completed in 1994 at roughly the same time as a synthesis by the group of Robert A. Holton, attracted national news media attention due to Taxol's structural complexity and its potent anti-cancer activity.[2][3]

Total syntheses accomplished

Books

He is also the co-author of three popular books on total synthesis:

  1. Classics in Total Synthesis I, 1996
  2. Classics in Total Synthesis II, 2003
  3. Classics in Total Synthesis III, 2011

Additionally, he authored or co-authored several other books:

  1. Molecules That Changed the World, 2008
  2. Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials, 2002
  3. Selenium in Natural Products Synthesis, 1984

Awards

K. C. Nicolaou has received numerous awards and honors including:

References
  1. "K.C. Nicolaou". Retrieved May 27, 2020.
  2. Borman, Stu (February 21, 1994). "Total Synthesis of Anticancer Agent Taxol Achieved by Two Different Routes". Chemical & Engineering News. Vol. 72, no. 8. pp. 32–34. doi:10.1021/cen-v072n008.p032.
  3. Blakeslee, Sandra (February 15, 1994). "Race to Synthesize Cancer Drug Molecule Has Photo Finish". The New York Times. Retrieved August 22, 2013.
  4. "Arthur C. Cope Award". ACS. Retrieved January 19, 2015.
  5. "APS Member History". search.amphilsoc.org. Retrieved April 2, 2021.
  6. "New Fellows 2013". Royal Society. Retrieved July 30, 2013.
  1. ^ Nicolaou, Kyriacos Costa; E. J. Sorensen (1996). Classics in Total Synthesis: Targets, Strategies, Methods. Wiley-VCH. ISBN 978-3-527-29231-8.
  2. ^ Nicolaou, Kyriacos Costa; S. A. Snyder (2003). Classics in Total Synthesis II: More Targets, Strategies, Methods. Wiley-VCH. ISBN 978-3-527-30684-8.
  3. ^ Nicolaou, Kyriacos Costa; J.S. Chen (2011). Classics in Total Synthesis III: Further Targets, Strategies, Methods. Wiley-VCH. ISBN 978-3-527-32957-1.
  4. ^ "Benjamin Franklin Medal in Chemistry". Franklin Institute. 2011. Archived from the original on July 30, 2012. Retrieved December 23, 2011.
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