Love Is in the N₂-O₂-Ar-CO₂-Ne-He-CH₄

Mr. Smithers reminds Mr. Burns about Valentine's Day and tries to convince him to let the employees leave early to stay with their loved ones. Burns refuses, but Smithers convinces him to host a Sweethearts Dance. While enjoying the party with Marge, Homer gets a phone call from Grampa saying that he is alone and scared that a cat who can smell death is staring at him. Homer and Marge visit Grampa at the Retirement Castle, where a nurse gives a pill to the elders, making them hallucinate and start dancing with the ghosts of late loved ones, including Grampa deceased wife Mona. Marge thinks it is not fair to do that to the old folks and decides to do something about it.

Meanwhile, at the party, Professor Frink is alone because he is not good at getting a girlfriend. The next day, Homer discovers him sleeping in one of the power plant's rooms. Frink confesses that Valentine's Day is hard for people like him. Homer explains that love is a matter of trial and error. Frink gets the idea of determining what women like in a man and using science to become that person. Frink replaces his glasses with invisible blue contact lenses and uses shoe lifts for him to look taller, but even a droid that he programmed to say "yes" still thinks he is not attractive. Homer suggests it could be because of his voice, so Frink decides to use a chip under his tongue to make his voice more attractive.

To test his new self, Frink goes to a yoga class. He manages to impress all the girls in there and eventually begins an active dating life, but he soon notices that he cannot handle his new life and decides to hide inside Moe's Tavern, where he realizes that most men there are lonely. He brings all the women to Springfield Planetarium, but instead of telling which woman he has chosen to be his girlfriend, he pairs them up with the lonely men of Springfield and goes back to his life as a single scientist. It is only then that the droid begins to see him as attractive while watching the stars, only to get interrupted by her mother as Frink wonders why he built the robot's mother.

At the Simpsons' house, Marge discovers that Bart is taking advantage of the old people's hallucinations to win money on gambling. She takes them back to the Retirement Castle, only to discover that the nurse gives powerful drugs to them only to ease her job. Marge manages to convince the nurse to stop medicating the old people. Though the nurse hides the drugs in the library, Grampa finds the pills and takes them, so he can start hallucinating and win Mona back, running out of the Retirement Castle and into a 1940s-esque world. During his hallucination, Marge, Bart and Lisa convince Grampa to leave the past behind and live in the present, where there are people that still love him. He says goodbye to Mona before waking up in a mechanic's garage, having somehow wandered there during his hallucination.

In the final scene, Marge experiences the hallucinations and asks Grampa why they are there again. He explains that he flushed the drugs down the toilet, but suspects that the drugs may have entered Springfield's water system. Marge thinks they should wake up, but is distracted by Homer calling attention to Dean Martin's presence.

Professor Frink's transformation is similar to the one from the 1963 film The Nutty Professor, whose main character is the basis for Frink. The female robot that Frink builds looks similar to the one from the 2014 film Ex-Machina.[1] Homer is looking at a poster for the 1943 film The Outlaw.[2]

"Love Is in the N₂-O₂-Ar-CO₂-Ne-He-CH₄" received a 1.3 rating and was watched by 2.89 million viewers, making it Fox's highest rated show of the night.[3]

Dennis Perkins of The A.V. Club gave the episode a B−, stating that the episode, "This episode (fine, 'Love Is in the N2-O2-Ar-CO2-Ne-He-CH4') is a moderately amusing mush of good and bad ideas making up two half-realized stories. I found things to like in both, and wished each were better, and longer."[1]

Tony Sokol of Den of Geek gave the episode 3.5 out of 5 stars. He stated that the episode is well-paced and fun, but it was a remake of Jerry Lewis material.[2]

• "Love Is in the N2-O2-Ar-CO2-Ne-He-CH4" at IMDb