MAD2L2

Mitotic spindle assembly checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene.[5][6]

MAD2L2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAD2L2, MAD2B, POLZ2, REV7, MAD2 mitotic arrest deficient-like 2 (yeast), mitotic arrest deficient 2 like 2, FANCV
External IDsOMIM: 604094 MGI: 1919140 HomoloGene: 4624 GeneCards: MAD2L2
Orthologs
SpeciesHumanMouse
Entrez

10459

71890

Ensembl

ENSG00000116670

ENSMUSG00000029003

UniProt

Q9UI95

Q9D752

RefSeq (mRNA)

NM_001127325
NM_006341

NM_027985
NM_001305420

RefSeq (protein)

NP_001120797
NP_006332

NP_001292349
NP_082261

Location (UCSC)Chr 1: 11.67 – 11.69 MbChr 4: 148.13 – 148.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1.[6]

Interactions

MAD2L2 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000116670 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029003 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C (Aug 1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–187. doi:10.1006/geno.1999.5831. PMID 10366450.
  6. "Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)".
  7. Nelson KK, Schlöndorff J, Blobel CP (Nov 1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343. 343 (3): 673–680. doi:10.1042/0264-6021:3430673. PMC 1220601. PMID 10527948.
  8. Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R (Feb 2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6): 4391–4397. doi:10.1074/jbc.275.6.4391. PMID 10660610.
  9. Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce CM, Fishel R, Takahashi M (Sep 2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7". J. Biol. Chem. 276 (38): 35644–35651. doi:10.1074/jbc.M102051200. PMID 11485998.

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.