MOCS3

Adenylyltransferase and sulfurtransferase MOCS3 is an enzyme that in humans is encoded by the MOCS3 gene.[5][6]

MOCS3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMOCS3, UBA4, molybdenum cofactor synthesis 3
External IDsOMIM: 609277 MGI: 1916622 HomoloGene: 6108 GeneCards: MOCS3
Orthologs
SpeciesHumanMouse
Entrez

27304

69372

Ensembl

ENSG00000124217

ENSMUSG00000074576

UniProt

O95396

A2BDX3

RefSeq (mRNA)

NM_014484

NM_001160330

RefSeq (protein)

NP_055299

NP_001153802

Location (UCSC)Chr 20: 50.96 – 50.96 MbChr 2: 168.07 – 168.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. One of the enzymes required for the biosynthesis of MoCo is molybdopterin synthase (MPT synthase, encoded by MOCS2/Mocs2 in mammals). The protein encoded by this gene adenylates and activates MPT synthase. This gene contains no introns. A pseudogene of this gene is present on chromosome 14.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000124217 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000074576 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Matthies A, Nimtz M, Leimkuhler S (May 2005). "Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry". Biochemistry. 44 (21): 7912–20. doi:10.1021/bi0503448. PMID 15910006.
  6. "Entrez Gene: MOCS3 molybdenum cofactor synthesis 3".

Further reading


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