2-Hydroxy-3-morpholinopropanesulfonic acid

MOPSO is a zwitterionic organic chemical buffering agent; one of Good's buffers. MOPSO and MOPS (3-morpholinopropanesulfonic acid) are chemically similar, differing only in the presence of a hydroxyl group on the C-2 of the propane moiety. It has a useful pH range of 6.5-7.9 in the physiological range, making it useful for cell culture work. It has a pKa of 6.9 with ΔpKa/°C of -0.015 and a solubility in water at 0°C of 0.75 M.

MOPSO
Chemical structure of MOPSO
Names
Preferred IUPAC name
2-Hydroxy-3-(morpholin-4-yl)propane-1-sulfonic acid[1][2]
Other names
MOPSO, 3-morpholino-2-hydroxypropanesulfonic acid, 3-morpholino-2HOPSA
Identifiers
3D model (JSmol)
ECHA InfoCard 100.063.607
EC Number
  • 269-989-6
UNII
  • InChI=1S/C7H15NO5S/c9-7(6-14(10,11)12)5-8-1-3-13-4-2-8/h7,9H,1-6H2,(H,10,11,12)
    Key: NUFBIAUZAMHTSP-UHFFFAOYSA-N
  • C1COCCN1CC(CS(=O)(=O)O)O
Properties
C7H15NO5S
Molar mass 225.259 g/mol
Appearance White crystalline powder
Melting point 270–290 °C (518–554 °F; 543–563 K)
Acidity (pKa) 6.9[3]
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Irritant
GHS labelling:
Warning
H315, H319, H335
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Flash point Non-flammable
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

MOPSO has been used as a buffer component for:[4]

See also

References
  1. "Compound Summary for CID 109333". PubChem. 2005-03-27.
  2. "MOPSO". Sigma-Aldrich.
  3. "Biological Buffers". Sigma-Aldrich.
  4. "MOPSO sodium salt" (PDF). Sigma-Aldrich.
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