Maleylpyruvate isomerase

In enzymology, a maleylpyruvate isomerase (EC 5.2.1.4) is an enzyme that catalyzes the chemical reaction

3-maleylpyruvate 3-fumarylpyruvate
maleylpyruvate isomerase
Identifiers
EC no.5.2.1.4
CAS no.9023-77-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Hence, this enzyme has one substrate, 3-maleylpyruvate, and one product, 3-fumarylpyruvate.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is 3-maleylpyruvate cis-trans-isomerase. This enzyme participates in tyrosine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2NSF and 2NSG.

References

    • Lack L (November 1961). "Enzymic cis-trans isomerization of maleylpyruvic acid". The Journal of Biological Chemistry. 236: 2835–40. PMID 14461395.


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