Musashi-1

RNA-binding protein Musashi homolog 1 also known as Musashi-1 is a protein that in humans is encoded by the MSI1 gene.[5][6]

MSI1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMSI1, musashi RNA binding protein 1
External IDsOMIM: 603328 MGI: 107376 HomoloGene: 55657 GeneCards: MSI1
Orthologs
SpeciesHumanMouse
Entrez

4440

17690

Ensembl

ENSG00000135097

ENSMUSG00000054256

UniProt

O43347

Q61474

RefSeq (mRNA)

NM_002442

NM_008629
NM_001376960
NM_001376961
NM_001376962
NM_001376963

RefSeq (protein)

NP_002433

NP_032655
NP_001363889
NP_001363890
NP_001363891
NP_001363892

Location (UCSC)Chr 12: 120.34 – 120.37 MbChr 5: 115.57 – 115.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein containing two conserved tandem RNA recognition motifs and functions as an RNA binding protein that is involved in post-transcriptional gene editing. It is a stem cell marker that controls the balance between self-renewal and terminal differentiation.[7][6]

Clinical significance

Over expression of this gene is associated with the grade of the malignancy and proliferative activity in gliomas and melanomas.[7] An increased expression of MSI1 protein is observed in endometriosis and endometrial carcinoma[8] siRNA-mediated inhibition of MSI expression in endometrial carcinoma cells induces apoptosis and inhibits cell proliferation by affecting the Notch signaling pathway[9]

MSI1 is highly expressed in neural progenitor cells and is required for normal development of the brain. A mutation in these gene is responsible for autosomal recessive primary microcephaly. MSI1 also interacts with the Zika virus genome and may explain why these cells are highly susceptible to Zika virus infection.[10][11]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000135097 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000054256 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Good P, Yoda A, Sakakibara S, Yamamoto A, Imai T, Sawa H, Ikeuchi T, Tsuji S, Satoh H, Okano H (September 1998). "The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells". Genomics. 52 (3): 382–4. doi:10.1006/geno.1998.5456. PMID 9790759.
  6. "Entrez Gene: MSI1 musashi homolog 1 (Drosophila)".
  7. Glazer RI, Vo DT, Penalva LO (2012). "Musashi1: an RBP with versatile functions in normal and cancer stem cells". Frontiers in Bioscience. 17 (1): 54–64. doi:10.2741/3915. PMID 22201732.
  8. Götte, M; Wolf, M; Staebler, A; Buchweitz, O; Kelsch, R; Schüring, AN; Kiesel, L (2008). "Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma". Journal of Pathology. 215 (3): 317–29. doi:10.1002/path.2364. PMID 18473332. S2CID 206323361.
  9. Götte, M; Greve, B; Kelsch, R; Müller-Uthoff, H; Weiss, K; Kharabi Masouleh, B; Sibrowski, W; Kiesel, L; Buchweitz, O (2011). "The adult stem cell marker Musashi-1 modulates endometrial carcinoma cell cycle progression and apoptosis via Notch-1 and p21WAF1/CIP1". International Journal of Cancer. 129 (8): 2042–2049. doi:10.1002/ijc.25856. PMID 21165952. S2CID 35338227.
  10. Chavali PL, Stojic L, Meredith LW, Joseph N, Nahorski MS, Sanford TJ, Sweeney TR, Krishna BA, Hosmillo M, Firth AE, Bayliss R, Marcelis CL, Lindsay S, Goodfellow I, Woods CG, Gergely F (2017). "Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication". Science. 357 (6346): 83–88. Bibcode:2017Sci...357...83C. doi:10.1126/science.aam9243. PMC 5798584. PMID 28572454.
  11. Griffin DE (2017). "Why are neurons susceptible to Zika virus?". Science. 357 (6346): 33–34. Bibcode:2017Sci...357...33G. doi:10.1126/science.aan8626. PMID 28684491.

Further reading


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