MAL (gene)

Myelin and lymphocyte protein is a protein that in humans is encoded by the MAL gene.[5]

MAL
Identifiers
AliasesMAL, mal, T-cell differentiation protein, mal, T cell differentiation protein, MVP17, VIP17
External IDsOMIM: 188860 MGI: 892970 HomoloGene: 7827 GeneCards: MAL
Orthologs
SpeciesHumanMouse
Entrez

4118

17153

Ensembl

ENSG00000172005

ENSMUSG00000027375

UniProt

P21145

O09198

RefSeq (mRNA)

NM_022440
NM_002371
NM_022438
NM_022439

NM_001171187
NM_010762

RefSeq (protein)

NP_002362
NP_071883
NP_071884
NP_071885

NP_001164658
NP_034892

Location (UCSC)Chr 2: 95.03 – 95.05 MbChr 2: 127.48 – 127.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.[5] The MAL protein is also thought to interact with the protein encoded by LSMEM1 based on two-hybrid screening.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000172005 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027375 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: MAL mal, T-cell differentiation protein".
  6. "LSMEM1". BioGRID. Retrieved 30 April 2015.

Further reading


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