Natalie Strynadka

Natalie C. J. Strynadka FRS[1] is a professor[7][8] of Biochemistry in the Department of Biochemistry and Molecular Biology at the University of British Columbia.[9][10][11][12][13]

Natalie Strynadka

FRS
Natalie Strynadka at the Royal Society admissions day in London, July 2015
Born
Natalie C. J. Strynadka

1963 (age 59–60)
Alma materUniversity of Alberta (BSc, PhD)
Awards
  • Prize Steacie (2002)
  • FRS (2015)[1]
Scientific career
Fields
Institutions
ThesisProbing molecular interactions at various levels of structural definition (1990)
Doctoral advisorMichael N. G. James[6]
Website

Education

Strynadka was educated at the University of Alberta where she was awarded a PhD in 1990.[14] Her thesis committee included Michael N. G. James and Sir David Chilton Phillips.[14]

Awards and honours

Strynadka was elected a Fellow of the Royal Society (FRS) in 2015. Her certificate of election reads:[1]

Natalie Strynadka is a pioneer in the study of proteins and protein assemblies essential to bacterial pathogenicity and antibiotic resistance. Her agenda-setting dissection of the membrane assemblies involved in infection, virulence and bacterial cell wall synthesis is having major impact in the development of therapeutic agents; both antibiotics and vaccines.

References
  1. Anon (2015). "Professor Natalie Strynadka FRS". London: royalsociety.org. Archived from the original on 12 May 2015.
  2. Lovering, A. L.; De Castro, L. H.; Lim, D; Strynadka, N. C. (2007). "Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis". Science. 315 (5817): 1402–5. Bibcode:2007Sci...315.1402L. doi:10.1126/science.1136611. PMID 17347437. S2CID 41658295.
  3. Wilke, M. S.; Heller, M; Creagh, A. L.; Haynes, C. A.; McIntosh, L. P.; Poole, K; Strynadka, N. C. (2008). "The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR". Proceedings of the National Academy of Sciences. 105 (39): 14832–7. Bibcode:2008PNAS..10514832W. doi:10.1073/pnas.0805489105. PMC 2567453. PMID 18812515.
  4. Strynadka, N. C.; Jensen, S. E.; Johns, K; Blanchard, H; Page, M; Matagne, A; Frère, J. M.; James, M. N. (1994). "Structural and kinetic characterization of a beta-lactamase-inhibitor protein". Nature. 368 (6472): 657–60. Bibcode:1994Natur.368..657S. doi:10.1038/368657a0. PMID 8145854. S2CID 25485212.
  5. King, A. M.; Reid-Yu, S. A.; Wang, W; King, D. T.; De Pascale, G; Strynadka, N. C.; Walsh, T. R.; Coombes, B. K.; Wright, G. D. (2014). "Aspergillomarasmine a overcomes metallo-β-lactamase antibiotic resistance". Nature. 510 (7506): 503–6. Bibcode:2014Natur.510..503K. doi:10.1038/nature13445. PMC 4981499. PMID 24965651.
  6. Strynadka, N. C. J.; James, M. N. G. (1989). "Crystal Structures of the Helix-Loop-Helix Calcium-Binding Proteins". Annual Review of Biochemistry. 58: 951–98. doi:10.1146/annurev.bi.58.070189.004511. PMID 2673026.
  7. "Strynadka laboratory". strynadkalab.biochem.ubc.ca. Archived from the original on 12 August 2015.
  8. "Natalie C.J. Strynadka, PhD: Senior International Research Scholar / 2012–Present". hhmi.org. Archived from the original on 18 May 2015.
  9. Strynadka, N. C.; Adachi, H; Jensen, S. E.; Johns, K; Sielecki, A; Betzel, C; Sutoh, K; James, M. N. (1992). "Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 a resolution". Nature. 359 (6397): 700–5. Bibcode:1992Natur.359..700S. doi:10.1038/359700a0. PMID 1436034. S2CID 4253788.
  10. Paetzel, M; Karla, A; Strynadka, N. C.; Dalbey, R. E. (2002). "Signal peptidases". Chemical Reviews. 102 (12): 4549–80. doi:10.1021/cr010166y. PMID 12475201.
  11. Gao, S; Kinzig, K. P.; Aja, S; Scott, K. A.; Keung, W; Kelly, S; Strynadka, K; Chohnan, S; Smith, W. W.; Tamashiro, K. L.; Ladenheim, E. E.; Ronnett, G. V.; Tu, Y; Birnbaum, M. J.; Lopaschuk, G. D.; Moran, T. H. (2007). "Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake". Proceedings of the National Academy of Sciences. 104 (44): 17358–63. doi:10.1073/pnas.0708385104. PMC 2077261. PMID 17956983.
  12. Zarivach, R; Deng, W; Vuckovic, M; Felise, H. B.; Nguyen, H. V.; Miller, S. I.; Finlay, B. B.; Strynadka, N. C. (2008). "Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS". Nature. 453 (7191): 124–7. Bibcode:2008Natur.453..124Z. doi:10.1038/nature06832. PMID 18451864. S2CID 205212689.
  13. Natalie Strynadka publications indexed by the Scopus bibliographic database. (subscription required)
  14. Strynadka, Natalie C. J. (1990). Probing molecular interactions at various levels of structural definition (PhD thesis). University of Alberta. doi:10.7939/R37D2QG6S. OCLC 70312424. ProQuest 230755977. open access


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