Neuropeptide B
Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.[5][6] It is expressed throughout the CNS with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.
| NPB | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | NPB, L7, PPL7, PPneuropeptide B | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 607996 MGI: 2387153 HomoloGene: 102151 GeneCards: NPB | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
References
- GRCh38: Ensembl release 89: ENSG00000183979 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000044034 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". British Journal of Pharmacology. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
- Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion". Results and Problems in Cell Differentiation. 46: 239–56. doi:10.1007/400_2007_056. ISBN 978-3-540-78350-3. PMID 18204824.
External links
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.