GNA11

GNA11
Identifiers
Aliases	GNA11, FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2, G protein subunit alpha 11, HG1K
External IDs	OMIM: 139313 MGI: 95766 HomoloGene: 20474 GeneCards: GNA11
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	3,123,999 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	81,381,024 bp[2]
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; pancreatic ductal cell; ; duodenum; ; secondary oocyte; ; cerebellar vermis; ; parotid gland; ; stromal cell of endometrium; ; nipple; ; rectum; ; saphenous vein;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; duodenum; ; jejunum; ; ileum; ; intestinal villus; ; left colon; ; Paneth cell; ; calvaria; ; condyle; ; ankle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; type 2A serotonin receptor binding; GTP binding; metal ion binding; guanyl nucleotide binding; G protein-coupled receptor binding; GTPase activity; signal transducer activity; G-protein beta/gamma-subunit complex binding; protein binding;
Cellular component	cytoplasm; membrane; plasma membrane; photoreceptor outer segment; lysosomal membrane; extracellular exosome; heterotrimeric G-protein complex;
Biological process	G protein-coupled acetylcholine receptor signaling pathway; skeletal system development; regulation of melanocyte differentiation; entrainment of circadian clock; platelet activation; heart development; cellular response to pH; phospholipase C-activating dopamine receptor signaling pathway; phototransduction, visible light; developmental pigmentation; action potential; signal transduction; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2767
	14672
	ENSG00000088256
	ENSMUSG00000034781
	P29992
	P21278
	NM_002067
	NM_010301
	NP_002058
	NP_034431
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene.[5][6] Together with GNAQ (its paralogue), it functions as a Gq alpha subunit.[7]

References

GRCh38: Ensembl release 89: ENSG00000088256 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034781 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.
"Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)".
139313 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-11; GNA11 at OMIM. Retrieved January 1, 2015.

Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacol. Ther. 92 (2–3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.
Jiang M, Pandey S, Tran VT, Fong HK (1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907–11. Bibcode:1991PNAS...88.3907J. doi:10.1073/pnas.88.9.3907. PMC 51562. PMID 1902575.
Thomas CP, Dunn MJ, Mattera R (1996). "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways". Biochem. J. 312 (1): 151–8. doi:10.1042/bj3120151. PMC 1136238. PMID 7492305.
Offermanns S, Simon MI (1995). "G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C". J. Biol. Chem. 270 (25): 15175–80. doi:10.1074/jbc.270.25.15175. PMID 7797501.
Stanners J, Kabouridis PS, McGuire KL, Tsoukas CD (1996). "Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling". J. Biol. Chem. 270 (51): 30635–42. doi:10.1074/jbc.270.51.30635. PMID 8530500.
Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. Bibcode:1996PNAS...93..116L. doi:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586.
Launay JM, Birraux G, Bondoux D, et al. (1996). "Ras involvement in signal transduction by the serotonin 5-HT2B receptor". J. Biol. Chem. 271 (6): 3141–7. doi:10.1074/jbc.271.6.3141. PMID 8621713.
Johnson GJ, Leis LA, Dunlop PC (1996). "Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences". Biochem. J. 318 (3): 1023–31. doi:10.1042/bj3181023. PMC 1217719. PMID 8836152.
Kinsella BT, O'Mahony DJ, Fitzgerald GA (1997). "The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha". J. Pharmacol. Exp. Ther. 281 (2): 957–64. PMID 9152406.
Wise A, Parenti M, Milligan G (1997). "Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association". FEBS Lett. 407 (3): 257–60. doi:10.1016/S0014-5793(97)00300-1. PMID 9175863. S2CID 85622146.
Carrasco MP, Asbóth G, Phaneuf S, López Bernal A (1998). "Activation of the prostaglandin FP receptor in human granulosa cells". J. Reprod. Fertil. 111 (2): 309–17. doi:10.1530/jrf.0.1110309. PMID 9462300.
Qian A, Wang W, Sanborn BM (1998). "Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11)". Cell. Signal. 10 (2): 101–5. doi:10.1016/S0898-6568(97)00097-1. PMID 9481484.
Dulin NO, Sorokin A, Reed E, et al. (1999). "RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11". Mol. Cell. Biol. 19 (1): 714–23. doi:10.1128/MCB.19.1.714. PMC 83928. PMID 9858594.
Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling". J. Biol. Chem. 274 (34): 23707–18. doi:10.1074/jbc.274.34.23707. PMID 10446129.
Brydon L, Roka F, Petit L, et al. (2000). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins". Mol. Endocrinol. 13 (12): 2025–38. doi:10.1210/mend.13.12.0390. PMID 10598579.
Corbetta S, Mantovani G, Lania A, et al. (2000). "Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia". Clin. Endocrinol. 52 (3): 339–48. doi:10.1046/j.1365-2265.2000.00933.x. PMID 10718832. S2CID 39998840.
Shraga-Levine Z, Sokolovsky M (2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific". Cell. Mol. Neurobiol. 20 (3): 305–17. doi:10.1023/A:1007010125316. PMID 10789830. S2CID 21841332.
AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U (2001). "The angiotensin II AT2 receptor is an AT1 receptor antagonist". J. Biol. Chem. 276 (43): 39721–6. doi:10.1074/jbc.M105253200. PMID 11507095.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000088256 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034781 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1302014-5] Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.

[entrez-6] "Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)".

[7] 139313 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-11; GNA11 at OMIM. Retrieved January 1, 2015.

GNA11

See also

References

Further reading