Next (Crichton novel)

A number of characters, including transgenic animals, try to survive in a world dominated by genetic research, corporate greed, and legal interventions.

"This novel is fiction, except for the parts that aren't."[1][2][3]

Frank Burnet has contracted an aggressive form of leukemia, and undergoes intensive treatment and four years of semiannual checkups. He later learned the checkups were a pretext for researching the genetic basis of his unusually successful response to treatment, and the physician's university had sold the rights to Frank's cells to BioGen, a biotechnology startup company. As the book opens Frank is suing the university for unauthorized misuse of his cells, but the trial judge rules that the cells were "waste" and that the university could dispose of them as it wished. Frank's lawyers advise that the university, as a tax-funded organization, can still claim the rights to the cells under the doctrine of eminent domain.

Ruthless venture capitalist "Jack" Watson conspires to steal or sabotage BioGen's cultures of Frank's cells. As part of his terms for financing BioGen, Watson previously forced the company to accept his irresponsible nephew Brad Gordon as its security chief. After Brad's carelessness nearly allows one of Watson's sabotage attempts to succeed, the company takes advantage of Brad's attraction to teenage girls, and engineers his being accused and convicted of raping a minor. Watson's price for providing a defense lawyer is that Brad must contaminate BioGen's cultures. Brad's lawyer plans to claim in defense that Brad has a gene for recklessness and instructs him to engage in various high-risk activities. As a result, Brad gets into a fight with a pair of martial arts experts and is finally shot by the police.

After Brad's sabotage, BioGen consults lawyers, who advise that under United States law they have the rights to all of Frank's cell line and thus the right to extract replacement cells, by force if necessary, from Frank or any of his descendants. When Frank goes on the run, BioGen hires bounty hunter Vasco Borden to obtain such cells, regardless of whether the donors consent. Vasco plans to snatch Frank's grandson Jamie from his school but is foiled by Jamie's mother Alex, whom he tries to seize instead. After escaping, Alex and Jamie also go on the run.

Henry Kendall, a researcher at another biotech company, finds that his illegal introduction of human genes into a chimpanzee a few years ago while working at the NIH primate research facility unexpectedly produced a transgenic chimpanzee, who can talk and whose behavior is generally childlike but reverts to chimpanzee patterns under stress. The agency intends to destroy the chimp-boy, Dave, in order to cover up the unauthorized experiment, but Henry sneaks him out of the lab. Henry's wife Lynn strongly opposes bringing Dave into their home, but their son, also named Jamie, becomes close friends with him. Lynn becomes Dave's most determined defender and, to explain Dave's odd appearance, publishes online reports of a fictitious genetic disease. She grooms him as a senior female would groom a very young chimpanzee in the wild. Dave is sent to the same school as Jamie and gets into trouble after biting the leader of a gang of bullies who attack Jamie. The chimp-boy becomes increasingly isolated at school; academically, he is backward in some areas such as writing, while in sports, his classmates regard him as unfair competition.

Paris-based animal behavior researcher Gail Bond finds that her two-year-old grey parrot, Gerard, into which human genes were injected while he was a chick, has been helping her son produce near-perfect homework. While she is testing Gerard's abilities, the bird becomes bored and mimics the voices and other sounds of her husband having sex in their home with another woman. After a quarrel, Gail's husband, an investment banker, gives Gerard as a "money can't buy this" present to an influential and lecherous client. The client finds Gerard an embarrassment and passes him on to another owner, and so on. Eventually, Gerard ends up in the hands of Stan Milgram, who loses patience with Gerard's loquacity while delivering the parrot to yet another owner three days' drive away and leaves the bird by the roadside. Gerard flies out off in search of more pleasant surroundings.

After a few more narrow escapes, Alex and Jamie head for the home of Lynn, who happens to be a childhood friend. Vasco anticipates this move and tries to snatch Jamie – but abducts Lynn's son Jamie instead. Dave saves Lynn's Jamie, biting off Vasco's ear and damaging the ambulance in which Vasco planned to extract the tissue samples. However, Vasco's associate snatches Alex's son while everyone is celebrating the rescue of Lynn's. While the hunt is going on, Biogen's lawyers apply for a warrant to arrest Alex, on the grounds that she had stolen the company's property, namely her and her son's cells. She has to go straight from the fight to the courtroom, where her lawyer outplays Biogen's, and the judge adjourns to check details of the relevant laws and precedents overnight. Alex and Henry discover that Alex's son is being moved to a private clinic where the tissue samples are to be taken. As they move in to retrieve him, Gerard, now a resident of the clinic's gardens, reminds Jamie to shout for his mother, who rescues him. Vasco gives up after Dave attacks him, and Alex threatens him with a shotgun. The next day the judge rules in Alex's favor and rejects the precedents as attempts to abolish normal human feelings by decree, a violation of the Thirteenth Amendment to the United States Constitution, which forbids slavery. The ruling will likely hamper research in the long run, and prevent patients from selling their tissues rather than donating them for research.

Gerard is welcomed into Lynn's home. After he mimics telephone dial tones Lynn contacts Gail, and he is reunited with her. Press commentators praise the household as a trend-setting inter-species transgenic family, and Henry is honored by some scientific organizations.

In other plot threads:

• BioGen researcher Josh Winkler's drug-addicted brother, Adam, accidentally exposes himself to a "maturity" gene that the company is developing for the control of irresponsible and addictive behavior. After Adam reforms within a few days, their mother pressures Josh to administer the gene to friends and relatives who also behave irresponsibly. By the end of the book all of his rat and human subjects die of accelerated old age.
• The staff at a hospital provide samples from corpses for use by unscrupulous relatives in lawsuits, sell corpses' bones for medical uses, and destroy records and samples to cover their tracks.
• Henry Kendall's boss Dr. Robert Bellarmino, a mediocre scientist but skillful manipulator, is also a lay preacher and slants his comments to journalists, schoolchildren and politicians according to whether his audience has religious or pro-science inclinations. He is ultimately shot by Brad Gordon at an amusement park. Ironically, Bellarmino was only at the park to look for people who might have the gene for recklessness, and Gordon was only there to bolster the evidence for his lawyer's case that he has the gene.
• An orangutan in Sumatra becomes famous for its ability to speak obscene statements in Dutch and French. An adventurer overdoses the orangutan with tranquillizer while trying to capture it, and has to give it mouth-to-mouth resuscitation. As a result, the orangutan catches the adventurer's cold and dies from a respiratory infection. An expert who dissects its corpse finds that its throat is very human-like but concludes from the shape of its skull that its brain is pure orangutan.
• An avant garde artist uses genetic modification to change the appearance of animals, while another self-named "artist/biologist" is falsely accused of modifying turtles so that females laying eggs are less vulnerable to predators because the turtles' genetically engineered bioluminescence attracts tourists. An advertising agency proposes to make genetically engineered animals and plants carry advertisements, and claims that this would be a very effective conservation strategy.
• Billionaire "Jack" Watson becomes the victim of an extremely aggressive form of genetic cancer, and is very nearly unable to receive treatment due to others' patents on the relevant genes, giving Watson "a taste of his own medicine". He eventually procures experimental treatment, which fails to save his life.
• In a meeting, several prominent US Senators begin discussing various issues related to genetic modification, and realize that the science is outpacing the ability of the political system to introduce laws dealing with it.

The book also features news reports, many about the genetics of blondes and of Neanderthals. These two themes combine into reports that Neanderthals were the first blondes, were more intelligent than Cro-Magnon humans and interbred with Cro-Magnons out of pity, and that "cavemen preferred blondes". At one point three successive reports feature a scientist's press release that Neanderthals had a gene that made them both behaviorally conservative and ecologically conservationist, an environmentalist's interpretation of that press release that modern humans need to learn from the Neanderthals lest they too become extinct, and a business columnist's interpretation that over-caution caused the Neanderthals' extinction.

Michael Crowley of The New Republic alleged that, in retaliation for his having written a negative review of Crichton's previous novel State of Fear, Crichton named a character with a small penis who rapes a baby after him. From page 227: "Alex Burnet was in the middle of the most difficult trial of her career, a rape case involving the sexual assault of a two-year-old boy in Malibu. The defendant, thirty-year-old Mick Crowley, was a Washington-based political columnist who was visiting his sister-in-law when he experienced an overwhelming urge to have anal sex with her young son, still in diapers." Both the real and the fictional Crowley are Washington-based political columnists who had graduated from Yale.[24]