Niels Kaj Jerne

Niels Kaj Jerne, FRS[1] (23 December 1911 – 7 October 1994) was a Danish immunologist. He shared the Nobel Prize in Physiology or Medicine in 1984 with Georges J. F. Köhler and César Milstein "for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies".[2]

Niels Kaj Jerne
Niels Kaj Jerne in 1950
Born23 December 1911
London, UK
Died7 October 1994(1994-10-07) (aged 82)
Castillon-du-Gard, France
NationalityDanish
Known forMonoclonal antibodies
Awards
Scientific career
FieldsImmunology

Jerne is known for three significant ideas. Firstly, instead of the body producing antibodies in response to an antigen, Jerne postulated that the immune system already has the specific antibodies it needs to fight antigens. Secondly, it was known that the immune system learns to be tolerant to the individual's own self. Jerne postulated that this learning takes place in the thymus. Thirdly, it was known that T cells and B cells communicate with each other.[3]

Jerne's network theory proposed that the active sites of antibodies are attracted to both specific antigens (idiotypes) and to other antibodies that bind to the same site. The antibodies are in balance, until an antigen disturbs the balance, stimulating an immune reaction.[4]

Early years and Education

His ancestors had lived on the small Danish island of Fanø for centuries, but, in 1910, his parents moved to London where Jerne was born in 1911.[4]

During the First World War his parents moved to the Netherlands and Jerne spent his youth in Rotterdam. After studying physics for two years at the Leiden University, Jerne moved to Copenhagen and changed his studies to the field of medicine. He graduated from the University of Copenhagen with a degree in medicine in 1947. Four years later, he was awarded the doctorate for his thesis, A Study of Avidity Based on Rabbit Skin Responses to Diphtheria Toxin-Antitoxin Mixtures.[5]

Research positions

From 1943 to 1956 Jerne was a research worker at the Danish National Serum Institute and during this time he formulated a theory on antibody formation. It is said that Jerne got his revolutionary scientific idea while bicycling across the Langebro bridge in Copenhagen on his way home from work.[6]

The antibody formation theory gave Jerne international recognition and in 1956 Jerne went to work for the World Health Organization in Geneva, where he served as the Head of the Sections of Biological Standards and of Immunology. He held this post for six years until moving to the United States and the University of Pittsburgh in 1962 to work as Professor of Microbiology and Chairman of the Department of Microbiology for four years. Jerne continued to do work for the World Health Organization as a member of the Expert Advisory Panel of Immunology from 1962 and onwards.

In 1966 Jerne moved back to Europe and took up the position of Professor of Experimental Therapy at the Johann Wolfgang Goethe University in Frankfurt. From 1966 to 1969 he was the Director of the Paul-Ehrlich-Institut, also in Frankfurt. In 1969 Jerne again switched jobs, this time to Basel in Switzerland, where he was the Director of the Basel Institute for Immunology until his retirement in 1980. During the 1970s and 1980s, Jerne was a pioneer in the development of immune network theory.

According to Jerne's biographer Thomas Söderqvist, Jerne was not a bench scientist, could not pipette accurately, and did not enjoy experimental work. His Nobel Prize was awarded for theories, rather than discoveries. Jerne developed the "natural selection theory of immunology", proposed by Paul Ehrlich 50 years earlier, although he was missing the clonal selection element proposed by David Talmage and then by Frank Macfarlane Burnet. It was met by skepticism among his colleagues at first, James Watson for example told Jerne bluntly that his theory "stinks".[7]

Family life

Jerne was married three times. He had two sons, Ivar Jerne (born 1936) and Donald Jerne (born 1941), with Tjek Jerne, a painter. Jerne had a third son, Andreas Wettstein, with Gertrud Wettstein, in 1971.[8]

According to Söderqvist, Tjek, 35, was distraught when she found out that Niels was having an affair with her best friend, Adda Sundsig-Hansen. Tjek had confided in Adda about her own affairs, and Adda had told Neils about them too. Niels demanded a divorce. Tjek begged him to stay. After he refused, she killed herself. Ivar woke up in the morning, smelled gas, and found his mother dead by the oven.[8] Jerne reportedly treated his second wife like a servant and nanny. He was serially unfaithful to his wives.[7]

Awards and honours

He was awarded honorary doctorates from

He was a member of

References
  1. Askonas, B. A.; Howard, J. G. (1997). "Niels Kaj Jerne. 23 December 1911 – 7 October 1994". Biographical Memoirs of Fellows of the Royal Society. 43: 237. doi:10.1098/rsbm.1997.0013. PMID 11619977. S2CID 45810507.
  2. "Niels K. Jerne, M.D." The American Association of Immunologists. Retrieved 27 October 2023.
  3. Ivan Lefkovits (1996). Portrait of the Immune System: Scientific Publications of Niels Kaj Jerne. World Scientific. pp. 745–748. ISBN 978-981-02-2614-5.
  4. "Niels K. Jerne" on Nobelprize.org , accessed 11 October 2020
  5. "Niels Jerne – Explaining the Human Immune System". SciHi Blog. 23 December 2017. Retrieved 21 June 2023.
  6. Dubiski, S. (10 March 2004). "Science as Autobiography: The Troubled Life of Niels Jerne". JAMA: The Journal of the American Medical Association. 291 (10): 1267–1268. doi:10.1001/jama.291.10.1267.
  7. Yewdell, Jonathan W. (October 2003). "He put the Id in Idiotype; book review of Science As Autobiography The Troubled Life of Niels Jerne by Thomas Söderqvist". EMBO Rep. 4 (10): 931. doi:10.1038/sj.embor.embor951. PMC 1326409.
  8. Soderqvist, Thomas (2008). "Ch. 9, "Letters are a Spiritual Spiderweb in Which you Snare the Dreaming Soul of a Woman"". Science as Autobiography: The Troubled Life of Niels Jern. Yale University Press. ISBN 978-0-300-12871-0.
  9. "Honorary Members". www.scandinavianimmunology.nu. Archived from the original on 10 October 2017. Retrieved 11 February 2018.

Bibliography
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