O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase
O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase (EC 2.9.1.2, MMPSepSecS, SepSecS, SLA/LP, O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase, O-phospho-L-seryl-tRNA:L-selenocysteinyl-tRNA synthase) is an enzyme with systematic name selenophosphate:O-phospho-L-seryl-tRNASec selenium transferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- O-phospho-L-seryl-tRNASec + selenophosphate ⇌ L-selenocysteinyl-tRNASec + phosphate
| O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Selenocysteine synthase tetramer, Mus musculus | |||||||||
| Identifiers | |||||||||
| EC no. | 2.9.1.2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
References
- Palioura S, Sherrer RL, Steitz TA, Söll D, Simonovic M (July 2009). "The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation". Science. 325 (5938): 321–5. Bibcode:2009Sci...325..321P. doi:10.1126/science.1173755. PMC 2857584. PMID 19608919.
- Araiso Y, Palioura S, Ishitani R, Sherrer RL, O'Donoghue P, Yuan J, Oshikane H, Domae N, Defranco J, Söll D, Nureki O (March 2008). "Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation". Nucleic Acids Research. 36 (4): 1187–99. doi:10.1093/nar/gkm1122. PMC 2275076. PMID 18158303.
- Aeby E, Palioura S, Pusnik M, Marazzi J, Lieberman A, Ullu E, Söll D, Schneider A (March 2009). "The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes". Proceedings of the National Academy of Sciences of the United States of America. 106 (13): 5088–92. Bibcode:2009PNAS..106.5088A. doi:10.1073/pnas.0901575106. PMC 2664009. PMID 19279205.
- Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D (December 2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proceedings of the National Academy of Sciences of the United States of America. 103 (50): 18923–7. Bibcode:2006PNAS..10318923Y. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313.
External links
- O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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