Osmosis Jones

Frank DeTorri is an unhealthy zookeeper at Sucat Memorial Zoo in Rhode Island. He copes with the death of his wife Maggie by overeating and foregoing basic hygiene, much to his daughter Shane's embarrassment. Inside his body, called the "City of Frank" by its anthropomorphic inhabitants, white blood cell Osmosis "Ozzy" Jones is a quick-witted officer of the Frank Police Department whose attempts to catch germs end up causing trouble in Frank's body.

One day, desperate to be re-elected, the corrupt Mayor Phlegmming doubles down on his junk food policies, ignoring their effect on Frank's health. This induces Frank to eat a boiled egg that fell into a chimpanzee's habitat, allowing Thrax, a virus known as "La Muerte Roja" ("The Red Death"), to enter his body. To placate his secretary Leah Estrogen, Phlegmming instructs Frank to take a cold pill, Special Agent Drixenol "Drix" Drixobenzometaphedramine, who disinfects the throat but unknowingly covers up evidence of Thrax's arrival. Ozzy is ordered to assist Drix's investigation while Thrax takes over a gang of sweat germs run by local crime boss Scabies and attacks the dam in Frank's nose, nearly killing Drix before Ozzy saves him.

Ozzy and Drix get into an argument, but after Ozzy reveals Thrax and his gang as the cause of the mucus dam breakage, Drix sticks with Ozzy. Ozzy tells Drix the reason for his poor reputation: Two years ago, Ozzy induced Frank to vomit a contaminated oyster onto Shane's science and P.E. teacher, Mrs. Boyd, causing Frank to be fired from his previous job at the pea soup factory and banned from visiting Shane's school, and Ozzy was demoted to patrol duty in the mouth for his role in the public humiliation. Drix agrees with Ozzy that he did the right thing, and the two pay a visit to Ozzy's informant, Chill, a flu vaccine cell who directs them to Thrax's hideout – a germ-ridden nightclub in a large zit on Frank's forehead. Ozzy goes undercover and infiltrates the gang, learning that Thrax, wanting to be known as the most dangerous virus in medical history, intends to masquerade as a common cold and use his knowledge of DNA to kill Frank within forty-eight hours. When Ozzy is discovered, Drix comes to his aid, causing a brawl which culminates in the zit being popped by a grenade. The pus lands on Mrs. Boyd's lip during a conversation with Frank, foiling his chance to apologize. Furious, Phlegmming closes the investigation, dismisses Ozzy from the force, and orders Drix to leave.

Having survived the zit's destruction, Thrax attacks the hypothalamus, stealing a crucial nucleotide before abducting Leah and preparing to flee via the mouth. His actions cause Frank to faint and develop a high fever, prompting his brother, Bob, to take him to the hospital, to Phlegmming's dismay. Ozzy discovers Thrax is alive and convinces Drix to stay. They reach Thrax in the uvula and save Leah, but Thrax uses pollen to induce Frank to sneeze him out of the mouth. Drix launches Ozzy after him, and they land on Shane's cornea. As they fight, falling onto one of Shane's false eyelashes, Ozzy tricks Thrax into trapping his hand in the lash and escapes as the lash falls into a beaker of alcohol, dissolving Thrax.

As Frank's temperature surpasses 108 °F (42 °C), he goes into cardiac arrest. Riding one of Shane's tears back to Frank's body, Ozzy revives him with the stolen nucleotide and Frank tells Shane "Mom says 'Hi.'" Congratulated as a hero and welcomed back into the police force, Ozzy enters a relationship with Leah, while Drix is allowed to stay as his new partner. Frank commits to a healthier lifestyle, leading Phlegmming to lose the election in a landslide to his opponent, Tom Colonic. Reduced to janitorial duty in the bowels, Phlegmming foolishly ignores a notice not to push a button that triggers Frank's flatulence, ejecting himself from the body in the process.

Osmosis Jones went through development hell during production. The animated sequences, directed by Tom Sito and Piet Kroon, went into production as planned even being completed ahead of schedule, but acquiring both a director and a star actor for the live-action sequences took a considerable amount of time, until Bill Murray was cast as the main character of Frank, and Peter and Bobby Farrelly stepped in to direct the live-action sequences. As part of their contract, the Farrelly brothers are credited as the primary directors of the film, although they did no supervision of the animated portions of the film. Will Smith was interested in the part of Ozzy, but in the end his schedule would not permit it.

Principal photography on the live-action scenes took place from April 2 to June 19, 2000 in Plymouth, Massachusetts.

Osmosis Jones was originally rated PG-13 by the MPAA for "crude language" and "bodily humor" in 2000. However, Warner Bros. edited the film to make it family-friendly; and in 2001 when it was released, the film was re-rated PG on appeal for "bodily humor".

A soundtrack containing hip hop and R&B music was released on August 7, 2001, by Atlantic Records. The soundtrack failed to chart on the Billboard 200, but Trick Daddy's single "Take It to da House" managed to make it to number 88 on the Billboard Hot 100 singles chart.

• Once Upon a Time... Life, an animated series with similar anthropomorphic representations of cells and germs.
• Ozzy & Drix, an animated series that serves as a continuation of the film.
• Cells at Work!, a Japanese manga/anime series with a similar premise.
• Inner Workings, a Disney short film that is set in the human body.

Wikiquote has quotations related to Osmosis Jones.

• Osmosis Jones at IMDb
• Osmosis Jones at The Big Cartoon DataBase