PARG

Poly (ADP-ribose) glycohydrolase is an enzyme that in humans is encoded by the PARG gene.[5][6][7]

PARG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPARG, PARG99, poly(ADP-ribose) glycohydrolase
External IDsOMIM: 603501 MGI: 1347094 HomoloGene: 50532 GeneCards: PARG
Orthologs
SpeciesHumanMouse
Entrez

8505

26430

Ensembl

ENSG00000227345

ENSMUSG00000021911

UniProt

Q86W56

O88622

RefSeq (mRNA)

NM_001303486
NM_001303487
NM_001303489
NM_003631
NM_001324381

NM_011960
NM_001359915
NM_001374221

RefSeq (protein)

NP_001290415
NP_001290416
NP_001290418
NP_001311310
NP_003622

NP_036090
NP_001346844
NP_001361150

Location (UCSC)Chr 10: 49.82 – 49.97 MbChr 14: 31.92 – 32.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Poly (ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly (ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000227345 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021911 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Poly (ADP-ribose) glycohydrolase". Retrieved 2011-11-08.
  6. Lin W, Amé JC, Aboul-Ela N, Jacobson EL, Jacobson MK (May 1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". J. Biol. Chem. 272 (18): 11895–901. doi:10.1074/jbc.272.18.11895. PMID 9115250.
  7. Amé JC, Apiou F, Jacobson EL, Jacobson MK (1999). "Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization". Cytogenet. Cell Genet. 85 (3–4): 269–70. doi:10.1159/000015310. PMID 10449915. S2CID 42156664.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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