PCDH18

PCDH18
Identifiers
Aliases	PCDH18, PCDH68L, protocadherin 18
External IDs	OMIM: 608287 MGI: 1920423 HomoloGene: 10389 GeneCards: PCDH18
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	137,532,494 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	49,711,774 bp[2]
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; Achilles tendon; ; parietal pleura; ; lactiferous duct; ; retinal pigment epithelium; ; tibia; ; placenta; ; visceral pleura; ; tibialis anterior muscle; ; endothelial cell;
	Top expressed in
	hand; ; maxillary prominence; ; dermis; ; left lung lobe; ; molar; ; foot; ; abdominal wall; ; body of femur; ; vas deferens; ; belly cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	brain development; homophilic cell adhesion via plasma membrane adhesion molecules; cell adhesion; cell-cell signaling; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	54510
	73173
	ENSG00000189184
	ENSMUSG00000037892
	Q9HCL0
	Q8VHR0
	NM_001300828; NM_019035
	NM_130448
	NP_001287757; NP_061908
NP_569715; NP_001391291; NP_001391292; NP_001391293; NP_001391295;
	NP_001391296; NP_001391306
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-18 is a protein that in humans is encoded by the PCDH18 gene.[5][6][7]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.[7]

References

GRCh38: Ensembl release 89: ENSG00000189184 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037892 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
Wolverton T, Lalande M (Sep 2001). "Identification and characterization of three members of a novel subclass of protocadherins". Genomics. 76 (1–3): 66–72. doi:10.1006/geno.2001.6592. PMID 11549318.
"Entrez Gene: PCDH18 protocadherin 18".

Suzuki ST (2000). "Recent progress in protocadherin research". Exp. Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Homayouni R, Rice DS, Curran T (2002). "Disabled-1 interacts with a novel developmentally regulated protocadherin". Biochem. Biophys. Res. Commun. 289 (2): 539–47. doi:10.1006/bbrc.2001.5998. PMID 11716507.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000189184 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037892 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10835267-5] Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.

[pmid11549318-6] Wolverton T, Lalande M (Sep 2001). "Identification and characterization of three members of a novel subclass of protocadherins". Genomics. 76 (1–3): 66–72. doi:10.1006/geno.2001.6592. PMID 11549318.

[entrez-7] "Entrez Gene: PCDH18 protocadherin 18".

PCDH18

References

Further reading