PIP4K2B

Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.[5][6][7][8]

PIP4K2B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPIP4K2B, PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
External IDsOMIM: 603261 MGI: 1934234 HomoloGene: 2634 GeneCards: PIP4K2B
Orthologs
SpeciesHumanMouse
Entrez

8396

108083

Ensembl

ENSG00000277292
ENSG00000276293

ENSMUSG00000018547

UniProt

P78356

Q80XI4

RefSeq (mRNA)

NM_003559
NM_138687

NM_054051

RefSeq (protein)

NP_003550

NP_473392

Location (UCSC)Chr 17: 38.77 – 38.8 MbChr 11: 97.61 – 97.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol 4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.[8]

Interactions

PIP4K2B has been shown to interact with TNFRSF1A.[5] In addition, PIP4K2B has been shown to interact with PIP4K2A and may modulate the cellular localisation of PIP4K2A.[9]

Structure

The structure of PIP4K2B has been determined through X-ray crystallography.[10]

References

  1. ENSG00000276293 GRCh38: Ensembl release 89: ENSG00000277292, ENSG00000276293 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018547 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV (Apr 1997). "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase". J Biol Chem. 272 (9): 5861–70. doi:10.1074/jbc.272.9.5861. PMID 9038203.
  6. Luoh SW, Venkatesan N, Tripathi R (Feb 2004). "Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage". Oncogene. 23 (7): 1354–63. doi:10.1038/sj.onc.1207251. PMID 14691457.
  7. Rameh LE, Tolias KF, Duckworth BC, Cantley LC (Nov 1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–6. Bibcode:1997Natur.390..192R. doi:10.1038/36621. PMID 9367159. S2CID 4403301.
  8. "Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta".
  9. Bultsma, Yvette; Keune, Willem-Jan; Divecha, Nullin (2010-09-01). "PIP4Kβ interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kα". Biochemical Journal. 430 (2): 223–235. doi:10.1042/bj20100341. ISSN 0264-6021. PMID 20583997.
  10. Rao, Vibha D; Misra, Saurav; Boronenkov, Igor V; Anderson, Richard A; Hurley, James H (1998). "Structure of Type IIβ Phosphatidylinositol Phosphate Kinase". Cell. 94 (6): 829–839. doi:10.1016/s0092-8674(00)81741-9. PMID 9753329. S2CID 18221569.

Further reading


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