Phosphatidylinositol 4-phosphate

Phosphatidylinositol-4-phosphate (PtdIns4P, PI-4-P, PI4P, or PIP) is a precursor of phosphatidylinositol (4,5)-bisphosphate. PtdIns4P is prevalent in the membrane of the Golgi apparatus.

In the Golgi apparatus, PtdIns4P binds to the GTP-binding protein ARF and to effector proteins, including four-phosphate-adaptor protein 1 and 2 (PLEKHA3 and PLEKHA8).[1] This three molecule complex recruits proteins that need to be carried to the cell membrane.[2]

There is now evidence that PI-4-P is capable of deforming lipid systems into tightly curved assemblies,[3][4] this is consistent with similar behaviour observed in phosphatidylinositol.

See also

References
  1. Godi A et al., FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat. Cell Biol. 2004 May;6(5):393-404.
  2. Choudhury RR, Hyvola N, Lowe M. Phosphoinositides and membrane traffic at the trans-Golgi network. Biochem Soc Symp. 2005;(72):31-8.
  3. Furse, Samuel; Brooks, Nicholas J.; Seddon, Annela M.; Woscholski, Rüdiger; Templer, Richard H.; Gaffney, Piers R. J.; Ces, Oscar (2012). "Lipid Membrane Curvature Induced by Distearoyl Phosphatidylinositol 4-Phosphate". Soft Matter. 8 (11): 3090–3093. doi:10.1039/c2sm07358g.
  4. Furse, Samuel; Brooks, Nicholas J.; Woscholski, Rüdiger; Gaffney, Piers R. J.; Templer, Richard H. (2016). "Pressure-dependent inverse bicontinuous cubic phase formation in a phosphatidylinositol 4-phosphate/phosphatidylcholine system". Chemical Data Collections. 3–4: 15–20. doi:10.1016/j.cdc.2016.08.001. hdl:10044/1/42515.


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