Pantoate 4-dehydrogenase
In enzymology, a pantoate 4-dehydrogenase (EC 1.1.1.106) is an enzyme that catalyzes the chemical reaction
- (R)-pantoate + NAD+ (R)-4-dehydropantoate + NADH + H+
pantoate 4-dehydrogenase | |||||||||
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Identifiers | |||||||||
EC no. | 1.1.1.106 | ||||||||
CAS no. | 37250-38-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are (R)-pantoate and NAD+, whereas its 3 products are (R)-4-dehydropantoate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NAD+ 4-oxidoreductase. Other names in common use include pantoate dehydrogenase, pantothenase, and D-pantoate:NAD+ 4-oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.
References
- Goodhue CT, Snell EE (1966). "The bacterial degradation of pantothenic acid. 3. Enzymatic formation of aldopantoic acid". Biochemistry. 5 (2): 403–8. doi:10.1021/bi00866a003. PMID 4287370.
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