Phosphatidylglycerol—membrane-oligosaccharide glycerophosphotransferase

In enzymology, a phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase (EC 2.7.8.20) is an enzyme that catalyzes the chemical reaction

phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose
phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase
Identifiers
EC no.2.7.8.20
CAS no.80146-86-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

Thus, the two substrates of this enzyme are phosphatidylglycerol and membrane-derived-oligosaccharide D-glucose, whereas its two products are 1,2-diacyl-sn-glycerol and membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups transferases for other substituted phosphate groups. The systematic name of this enzyme class is phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase. Other names in common use include phosphoglycerol transferase, oligosaccharide glycerophosphotransferase, and phosphoglycerol transferase I. This enzyme participates in glycerolipid metabolism.

References

    • Jackson BJ, Kennedy EP (1983). "The biosynthesis of membrane-derived oligosaccharides. A membrane-bound phosphoglycerol transferase". J. Biol. Chem. 258 (4): 2394–8. PMID 6296144.


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