Phosphatidylinositol diacylglycerol-lyase
The enzyme phosphatidylinositol diacylglycerol-lyase (EC 4.6.1.13) catalyzes the following reaction:
- 1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
| phosphatidylinositol diacylglycerol-lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.6.1.13 | ||||||||
| CAS no. | 37288-19-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming). Other names in common use include monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, 1-phosphatidylinositol phosphodiesterase, 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase, (cyclic-phosphate-forming), 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase, and (1,2-cyclic-phosphate-forming). It participates in inositol phosphate metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T6M and 2OR2.
References
- Allan D, Michell RH (1974). "Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0". Biochem. J. 142 (3): 591–7. doi:10.1042/bj1420591. PMC 1168323. PMID 4377210.
- Friedel RO, Brown JD, Durell (1967). "Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain". Biochim. Biophys. Acta. 144 (3): 684–6. doi:10.1016/0005-2760(67)90059-8. PMID 4294905.
- Irvine RF (1982). "The enzymology of stimulated inositol lipid turnover". Cell Calcium. 3 (4–5): 295–309. doi:10.1016/0143-4160(82)90018-5. PMID 6297738.
- Michell RH, Allan D (1975). "Inositol cyclis phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus)". FEBS Lett. 53 (3): 302–4. doi:10.1016/0014-5793(75)80041-X. PMID 236918. S2CID 5813981.
- Low MG, Finean JB (1977). "Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C". Biochem. J. 167 (1): 281–4. doi:10.1042/bj1670281. PMC 1183647. PMID 588258.
- Henner DJ, Yang M, Chen E, Hellmiss R, Rodriguez H, Low MG (1988). "Sequence of the Bacillus thuringiensis phosphatidylinositol specific phospholipase C". Nucleic Acids Res. 16 (21): 10383. doi:10.1093/nar/16.21.10383. PMC 338883. PMID 3194218.